TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE
- CAS Number:77278-63-8
- Molecular formula:C15H22N2O2
- Molecular Weight:262.35
92-54-6
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24424-99-5
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77278-63-8
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Yield:77278-63-8 99%
Reaction Conditions:
with 3a,6a-diphenylglycoluril in ethanol at 25 - 30; for 0.5 h;Reagent/catalyst;
Steps:
6. General procedure of diphenylglycoluril catalyzed N-tertbutoxycarbonylationof amines 3a-y
General procedure: In a 25 mL of round bottom flask, a solution of di-tert-butyldicarbonate (1 mmol) and Diphenyglycouril (10 mol %) were addedin 10 mL of ethanol. A turbid solutionwas obtained. In that solution1 mmol of Amine (1a-y) was added. Reaction mixture was stirredfor 30 min at room temperature. After total consumption of thestarting material (determination by TLC), the solvent was removedin vacuo, and the residue was isolated by column chromatographyon silica gel to get the pure product 3a-y as solid or oil.
References:
Awasthi, Amardeep;Mukherjee, Anagh;Singh, Mandeep;Rathee, Garima;Vanka, Kumar;Chandra, Ramesh [Tetrahedron,2020,vol. 76,# 23,art. no. 131223] Location in patent:supporting information
108-86-1
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57260-71-6
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77278-63-8
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591-50-4
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57260-71-6
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77278-63-8
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1193466-76-0
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1078-58-6
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77278-63-8
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92-54-6
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201230-82-2
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75-65-0
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77278-63-8
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