tert-butyl benzo[b]thiophen-2-ylcarbaMate synthesis
- Product Name:tert-butyl benzo[b]thiophen-2-ylcarbaMate
- CAS Number:89673-36-9
- Molecular formula:C13H15NO2S
- Molecular Weight:249.33
6314-28-9
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75-65-0
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89673-36-9
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$11.00/100mg
Yield:89673-36-9 94%
Reaction Conditions:
with diphenyl phosphoryl azide;N-ethyl-N,N-diisopropylamine for 8 h;Heating / reflux;
Steps:
1
Benzo[Z>]thiophen-2-yl-carbamic acid tert-butyl ester (1-B).; A solution of compound 1-A (14.4 g, 80.6 mmol), N,N-diisopropylethylamine (15.5 mL, 88.6 mmol) and diphenylphosphoryl azide (20.8 mL, 96.7 mmol) in -butanol (150 mL) was heated at reflux for 8 h. The solvent was evaporated in vacuo, and the residue purified by flash column chromatography on silica gel, eluting with dichloromethane, to afford compound 1-B as a colorless solid (18.9 g, 94%). 1H-NMR (DMSO-^): δ 1.50 (s, 9H),
References:
WO2009/12430,2009,A1 Location in patent:Page/Page column 180-181
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89673-36-9
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143944-01-8
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98-86-2
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89673-36-9
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39827-11-7
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89673-36-9
52 suppliers
$11.00/100mg