tert-butyl cyclobutanecarboxylate synthesis
- Product Name:tert-butyl cyclobutanecarboxylate
- CAS Number:87661-19-6
- Molecular formula:C9H16O2
- Molecular Weight:156.22
3721-95-7
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Yield:87661-19-6 77%
Reaction Conditions:
with 4-dimethylaminopyridine;dicyclohexyl-carbodiimide in dichloromethane;tert-butyl alcohol at 20; for 16 h;
Steps:
46.1 first step:
Dissolve cyclobutanecarboxylic acid (I-46-a) (5.0 g, 50.0 mmol) in dichloromethane (40 mL), add dicyclohexylcarbodiimide (11.0 g, 55.5 mmol) to the reaction solution, 4 - Dimethylaminopyridine (0.61 g, 5.0 mmol) and tert-butanol (7.4 g, 100.0 mmol), the reaction solution was stirred at room temperature for 16 hours.The reaction solution was concentrated and separated by silica gel column chromatography (petroleum ether/ethyl acetate=0-10%) to obtain the target compound cyclobutyl tert-butyl ester (I-46-b) (6.0 g, 77%)
References:
WO2022/143771,2022,A1 Location in patent:Page/Page column 75; 76
