Thiourea, N,N'-dioctyl- synthesis

5synthesis methods

Product Name:Thiourea, N,N'-dioctyl-
CAS Number:109-40-0
Molecular formula:C17H36N2S
Molecular Weight:300.55

75-15-0
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$40.00/100g

111-86-4
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$5.00/25g

109-40-0
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$172.00/250mg

Yield:109-40-0 98%

Reaction Conditions:

in lithium hydroxide monohydrate at 20; for 0.166667 h;Green chemistry;

Steps:

1,3-dioctylthiourea (Entry 6)

General procedure: To a 50 mL round bottom flask equipped with a magnetic stirrer, add carbon disulphide (5 mmol) andamine (10 mmol) in ice cold condition followed by addition of water (5 mL). Cork the flask. Thereaction mixture was stirred vigorously at room temperature. The progress of the reaction was checkedby TLC (10% MeOH: chloroform or EtOAc: hexane). After completion of reaction, solid was obtainedby removal of water under reduced pressure on rotary evaporator while in some cases (Entry 7, 9, 10,11 and 14, 15) the reaction mixture solidified when the reaction on completion. The obtained solidproduct was recrystallized with ethanol or washing with mixture EtOAc: hexane.

References:

Jangale, Asha D.;Kumavat, Priyanka P.;Wagh, Yogesh B.;Tayade, Yogesh A.;Mahulikar, Pramod P.;Dalal, Dipak S. [Synthetic Communications,2015,vol. 45,# 2,p. 236 - 244] Location in patent:supporting information

111-86-4
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$5.00/25g

141-82-2 Synthesis