Ticagrelor Related Compound 44 synthesis
- Product Name:Ticagrelor Related Compound 44
- CAS Number:1431867-40-1
- Molecular formula:C8H12ClN3OS
- Molecular Weight:233.72
1431867-39-8
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Yield:1431867-40-1 68%
Reaction Conditions:
with iron;acetic acid at 20; for 2 h;
Steps:
6 Example 6
Preparation of 4-chloro-6-methoxy-2-(propylthio)pyrimidin-5-amine (CMLINA)
To a solution of CMLIN (0.10 g, 0.57 mmol) in AcOH (2 mL) Fe (98 mg, 1.75 mmol) was added, and reaction mixture was then stirred at room temperature for 2 h.
Salts were then filtered off and filtrate concentrated. EtOAc was added (400 mL), organic layer was washed with water (3 x 200 mL), dried over MgSO4, and concentrated to afford oily product (0.60 g, 68% yield). MS (ESI) m/z: 234 [MH]+.
References:
EP2586773,2013,A1 Location in patent:Paragraph 0079-0080
145783-14-8
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