
2-Mercapto-4-methyl-5-thiazoleacetic acid synthesis
- Product Name:2-Mercapto-4-methyl-5-thiazoleacetic acid
- CAS Number:34272-64-5
- Molecular formula:C6H7NO2S2
- Molecular Weight:189.26

513-74-6

123-76-2

34272-64-5
To the reactor were added 100 kg of acetylpropionic acid and 1000 L of carbon tetrachloride. Under stirring conditions, 176 kg of sodium bromide was added, followed by a slow dropwise addition of 260 kg of hydrogen peroxide solution. The reaction mixture was heated to 60 °C and maintained at this temperature for 2.5 hours. Upon completion of the reaction, water was added for washing to separate the organic and aqueous phases. The aqueous phase was treated as waste water. To the organic phase, 75 kg of ammonium dithiocarbamate, 1000 kg of water and 22 kg of sodium carbonate were added directly to the organic phase to carry out the cyclization reaction. After completion of the reaction, the aqueous phase was acidified with acid at pH=1.5 to precipitate the product. Finally, 132 kg of 2-mercapto-4-methyl-5-thiazoleacetic acid was obtained with 99.92% purity and 80.99% yield.
Yield: 80.99%
Reaction Conditions:
Stage #1:levulinic acid with dihydrogen peroxide;sodium bromide in tetrachloromethane at 60; for 2.5 h;Large scale;
Stage #2:ammonium dithiocarbamate with sodium carbonate in tetrachloromethane;waterLarge scale;Reagent/catalyst;Temperature;Solvent;
Steps:
2 Example 2
Add 100kg of levulinic acid and 1000L of carbon tetrachloride to the reactor.After adding 176 kg of sodium bromide and stirring, slowly add 260 kg of hydrogen peroxide solution.Heat to 60°C for 2.5 hours, add water to wash, and separate organic phase.The aqueous phase treats the wastewater. To the organic phase, 75 kg of ammonium dithiocarbamate, 1000 kg of water, and 22 kg of sodium carbonate were directly added for the cyclization reaction.The aqueous phase is acidified with pH=1.5, obtaining2-mercapto-4-methyl-5-thiazoleacetic acid 132 kg, purity 99.92%,Yield 80.99%.
References:
Shandong Jincheng Pharmaceutical And Chemical Co., Ltd.;Sun Tingting;Du Hanyue;Ma Yongxiang;Zhao Qi;Li Shanshan CN107602503, 2018, A Location in patent:Paragraph 0024; 0025; 0026; 0027; 0028; 0029-0034

86329-79-5
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34272-64-5
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86329-79-5
202 suppliers
$28.00/25mg

104301-63-5
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34272-64-5
182 suppliers
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120533-30-4
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$185.00/10mg

69739-16-8
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$29.00/25mg

86329-79-5
202 suppliers
$28.00/25mg

104301-63-5
53 suppliers
inquiry

34272-64-5
182 suppliers
$13.00/1g

120533-30-4
39 suppliers
$185.00/10mg

69739-16-8
158 suppliers
$29.00/25mg