TIGLIC ACID synthesis
- Product Name:TIGLIC ACID
- CAS Number:13201-46-2
- Molecular formula:C5H8O2
- Molecular Weight:100.12
75-07-0
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13201-46-2
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Yield:-
Reaction Conditions:
with acetic anhydride;triethylamine at 120; for 48 h;
Steps:
2.3 Synthesis of PCA derivatives and its characterization
General procedure: PCA derivatives were synthesized using the Perkin reaction [12]. A mixture of a substituted phenylacetic acid (5.0g), a substituted benzaldehyde (1.0-1.2 equiv.), triethylamine (0.7 equiv.), and acetic anhydride (2.9 equiv.) was heated at 120°C for 48h. After cooling, water (50mL) and then 6N KOH aqueous solution (15mL) were added. After vigorous stirring overnight, the mixture was washed with ether (×2), and the resulting aqueous solution was neutralized by the addition of 2N HCl (100mL). After 30min, the precipitate was collected by filtration, dissolved in ethyl acetate with active charcoal, and the filtrate was concentrated and recrystallized using a mixture of ethanol and water.
References:
Atobe, Mahito;Fukazawa, Atsushi;Hashimoto, Yasushi;Sato, Yasushi;Tanaka, Kenta [Electrochemistry Communications,2020,vol. 115]
124-38-9
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106-99-0
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5204-64-8
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53774-20-2
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13201-46-2
29 suppliers
$31.00/250mg