trans-2-amino-N-(4-hydroxycyclohexyl)benzamide synthesis

Yield:15942-11-7 98.5%

Reaction Conditions:

in water at 10 - 40; for 2.5 h;Temperature;

Steps:

1; 2 Example 2: Synthesis of trans-4-[(2-aminobenzoyl)amino]cyclohexanol (Compound 4)

Add 7.45g (64.8mmol) of trans-4-aminocyclohexanol into a 500ml three-necked flask, add 150ml of water to dissolve the yellow-brown transparent liquid, add 10g (61.3mmol) of isatoic anhydride in batches at 1015, and react The liquid turned off-white and turbid, reacted in a water bath at 40°C, with continuous stirring and bubbles appeared, and then kept the reaction for 2.5 hours. TLC monitored the reaction to be complete. Then, it was filtered with suction to obtain trans-4-[(2-aminobenzoyl)amino]cyclohexanol (Compound 4), washed with 10ml of ice ethanol three times to take away the water, and dried under reduced pressure to obtain an off-white solid 14.14g with a yield 98.5%.

References:

CN112341347,2021,A Location in patent:Paragraph 0074-0077