2-AMINO-3,5-DIBROMOBENZYL ALCOHOL synthesis
- Product Name:2-AMINO-3,5-DIBROMOBENZYL ALCOHOL
- CAS Number:50739-76-9
- Molecular formula:C7H7Br2NO
- Molecular Weight:280.94
50910-55-9
519 suppliers
$6.00/5g
50739-76-9
195 suppliers
$17.00/250mg
Yield:50739-76-9 99.5%
Reaction Conditions:
with potassium borohydride in ethanol at 20; for 3 h;Temperature;Solvent;
Steps:
1.1; 2.1; 3.1; 1.1 1. Synthesis of 3,5-dibromo-2-aminobenzyl alcohol
Put 240kg of absolute ethanol and 100kg of 3,5-dibromo-2-aminobenzaldehyde into the cleaned and dried 1000L glass-lined reactor. After stirring evenly, slowly add 12kg of potassium borohydride in 6 times to control the reaction temperature. The reaction was stirred at 20°C for 3 hours. TLC checked that the reaction of the raw materials was complete. After the reaction is complete, the reaction liquid is placed in a 2000L reactor and cooled to 0-10°C for crystallization. Pack the clean centrifuge filter bag, put the material in the centrifuge for spin filtration, after putting it out, wash the material with water to neutral (check with pH test paper), and spin dry. Put the spin-dried intermediate into a clean stainless steel tray, spread it evenly, with a thickness of 1~2cm, place it on the drying frame, push it into the hot air circulating oven, turn off the oven, turn on the power and heat up to 80°C, and dry it in hot air circulation Bake until the moisture is less than 0.5% (6h), cool, take out, and weigh to obtain 100.20 kg of 3,5-dibromo-2-aminobenzyl alcohol with a yield of 99.5%.
References:
CN112266329, 2021, A Location in patent:Paragraph 0081-0087; 0099-0102; 0110-0113; 0121-0123
606-00-8
195 suppliers
$13.00/5g
50739-76-9
195 suppliers
$17.00/250mg
134-20-3
566 suppliers
$13.00/25mL
50739-76-9
195 suppliers
$17.00/250mg