Vorapaxar synthesis
- Product Name:Vorapaxar
- CAS Number:900161-12-8
- Molecular formula:C29H34N2O5
- Molecular Weight:490.59
900161-11-7
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Yield: 88.1%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 30; under 3800.26 Torr; for 16 h;
Steps:
11
Compound II 24.4g 120ml methanol was added and hydrogenation vessel was charged with mass percentage of 2.5 g of 10% palladium on carbon (mass percentage refers to the percentage of the mass of the total mass of the palladium accounts palladium on carbon), charged with hydrogen to a pressure of 5 atmospheric pressure, reacted at 30 16 hours discharge filtration, filtrate was concentrated under reduced pressure, column chromatography to give 21.6g solid compound I, 88.1% yield.
References:
Shanghai Bozhi Yan Xin Pharmaceutical Co., Ltd.;Ying Shuhuan;Pi Hongjun;Chen Jian CN106699712, 2017, A Location in patent:Paragraph 0221-0224
541-41-3
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$19.39/5g
900161-12-8
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