ChemicalBook CAS DataBase List YL-0919

YL-0919 synthesis

8synthesis methods

Product Name:YL-0919
CAS Number:1339339-18-2
Molecular formula:C18H22N2O2
Molecular Weight:298.38

142-08-5 Synthesis

142-08-5
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3612-20-2 Synthesis

3612-20-2
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1774-47-6 Synthesis

1774-47-6
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1339339-18-2
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Yield:1339339-18-2 88.9 %

Reaction Conditions:

Stage #1: 1-benzyl-4-piperidone;trimethylsulfoxonium iodidewith tetra(n-butyl)ammonium hydrogensulfate;sodium hydroxide in toluene at 65;Large scale;
Stage #2: 2-hydroxypyridin in toluene;Large scale;Reagent/catalyst;Temperature;

Steps:

1-4 Example 4

At room temperature, weigh 70.0kg N-benzyl-4-piperidone, 89.5kg trimethylsulfoxide iodide, 6.3kg tetrabutylammonium bisulfate, 490L toluene and mix, then add 39.5kg 15% sodium hydroxide Alkaline solution, heat up to 65°C and keep it warm for 4 hours, then add 38.7kg 2-hydroxypyridine, continue to react for 12 hours, after the reaction is over, let it stand for stratification, add an appropriate amount of drinking water to wash the toluene phase, concentrate the toluene phase to dryness, add an appropriate amount of ethanol to raise the temperature Dissolve, slowly cool down to -10°C, filter, and dry to obtain white piperapidone with a yield of 88.9% and a purity of 99.3%.

References:

CN115433162,2022,A Location in patent:Paragraph 0037-0044

142-08-5 Synthesis

142-08-5
494 suppliers
$6.00/5g