| Identification | More | [Name]
Di-n-butyl ether | [CAS]
142-96-1 | [Synonyms]
1,1'-OXYBIS(BUTANE)
1-BUTOXYBUTANE
BUTYL ETHER
DBE
DIBUTYL ETHER
DIBUTYL OXIDE
DI-N-BUTYL ETHER
DL-N-BUTYL ETHER
NBE
N-BUTYL ETHER
N-DIBUTYL ETHER
(n-C4H9)2O
1,1’-oxybis-butan
Butane, 1,1'-oxybis-
Butane,1,1’-oxybis-
Butane,1-butoxy-
Butyl oxide
butylethers
butyloxide
Ether butylique | [EINECS(EC#)]
205-575-3 | [Molecular Formula]
C8H18O | [MDL Number]
MFCD00009461 | [Molecular Weight]
130.23 | [MOL File]
142-96-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Butyl Ether is a flammable, colorless liquid with
a mild, ethereal odor. | [Melting point ]
-98 °C (lit.) | [Boiling point ]
142-143 °C (lit.) | [density ]
0.764 g/mL at 25 °C(lit.)
| [vapor density ]
4.48 (vs air)
| [vapor pressure ]
4.8 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.399(lit.)
| [Fp ]
77 °F
| [storage temp. ]
Flammables area | [solubility ]
H2O: soluble0.113g/L at 20°C | [form ]
Liquid | [color ]
Clear colorless | [Odor]
Mild, ether-like. | [PH]
5.2 (0.2g/l, H2O, 20℃) | [PH Range]
5.2 | [Relative polarity]
1.7 | [Stability:]
Stable. Flammable. May form peroxides in storage. Incompatible with strong oxidizing agents. | [explosive limit]
0.9-8.5%(V) | [Water Solubility ]
0.03 g/100 mL (20 ºC) | [Merck ]
14,1569 | [BRN ]
1732752 | [Dielectric constant]
3.1（25℃） | [InChIKey]
DURPTKYDGMDSBL-UHFFFAOYSA-N | [LogP]
3.35 | [Uses]
Solvent for hydrocarbons, fatty materials;
extracting agent used especially for separating met-
als, solvent purification, organic synthesis (reaction
medium).
| [CAS DataBase Reference]
142-96-1(CAS DataBase Reference) | [NIST Chemistry Reference]
n-Butyl ether(142-96-1) | [EPA Substance Registry System]
142-96-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 1149 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
EK5425000
| [Autoignition Temperature]
365 °F | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29091990 | [Safety Profile]
Mildly toxic by
inhalation, ingestion, and skin contact.
Human systemic effects by inhalation:
conjunctiva irritation and unspecified nasal
effects. An experimental skin and human
eye irritant. See also ETHERS. Dangerous
fire hazard when exposed to heat, flame, oroxidizers. Incompatible with NCL and
oxidizing materials. To fight fire, use alcohol
foam, dry chemical. When heated to
decomposition it emits acrid smoke and
fumes. | [Hazardous Substances Data]
142-96-1(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 7.4 g/kg (Smyth) |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid with an ethereal odor. Flash point below 141°F. Less dense than water and insoluble in water. Vapors heavier than air. Irritates the eyes, nose, throat, and respiratory tract. | [Reactivity Profile]
Ethers, such as BUTYL ETHER can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. | [Air & Water Reactions]
Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. A mixture of liquid air and diethyl ether exploded spontaneously [MCA Case History 616 1960]. Insoluble in water. | [Hazard]
Toxic on prolonged inhalation. Flammable,
moderate fire risk. May form explosive peroxides,
especially in anhydrous form. | [Health Hazard]
Inhalation causes irritation of nose and throat. Liquid irritates eyes and may irritate skin on prolonged contact. Ingestion causes irritation of mouth and stomach. | [Potential Exposure]
It is used as a solvent for hydrocarbons, fatty materials; extracting agent in used metals separation; solvent purification, making other chemicals.
Incompatibilities: May form explosive mixture with air.
May accumulate static electrical charges, and may cause
ignition of its vapors. Incompatible with strong acids; oxidizers. Contact with air or light may form unstable and
explosive peroxides, especially anhydrous form. | [Fire Hazard]
Behavior in Fire: Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. | [First aid]
this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has
stopped and CPR if heart action has stopped. Transfer
promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Give large
quantities of water and induce vomiting. Do not make an
unconscious person vomit | [Shipping]
UN1149 Butyl ethers & Dibutyl ethers, Hazard
Class: 3; Labels: 3—Flammable liquid | [Description]
Butyl ether (dibutyl ether) is a colorless, stable liquid, with a mild ether-like odor. It is immiscible with water, with a specific gravity of 0.8, which is lighter than water. Butyl ether is a moderate fire risk and will form explosive peroxides on aging. Flammable range is 1.5%–7.6% in air, with a boiling point of 286°F (141°C) and a flash point of 77°F (25°C). Ignition temperature is 382°F (194°C), and the vapor density is 4.5, which is heavier than air. In addition to flammability, butyl ether is toxic on prolonged inhalation. The four-digit UN identification number is 1149. The NFPA 704 designation is health 2, flammability 3, and reactivity 1. The primary use is as a solvent. | [Chemical Properties]
Di-n-butyl ether is a flammable, colorless liquid with a mild, ethereal odor.
| [Chemical Properties]
Di-n-butyl ether is colourless liquid with ether-like odour
| [Waste Disposal]
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed. | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Industrial uses]
n-Butyl ether is used in
synthesis reactions that require an anhydrous, inert solvent. This ether is a valuable
extraction solvent for aqueous solutions because of its low water solubility. n-Butyl
ether when mixed with ethanol or butanol is an excellent solvent for ethyl cellulose. | [Environmental Fate]
Butyl ether has the ability to dissolve lipids. As a result, it
causes irritation and pain on contact with the eyes and nasal
mucosa. It also causes dermal irritation and dermatitis on
contact with the skin. Damage caused by butyl ether appears
to be scattered loss of epithelial cells due to solution of
phospholipid cell membranes. At the central nervous system
(CNS) level, butyl ether, like other volatile organic solvents,
depresses the CNS by dissolving in the lipid membrane of the
cells and disrupting the lipid matrix. These effects are known
as membrane fluidization. At the molecular level, membrane
fluidization disrupts solute gradient homeostasis, which is
essential for cell function. | [storage]
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with butyl ether you should be trained onits proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Butylether must be stored in a cool, dark place, separated fromoxidizers (such as perchlorates, peroxides, permanganates,chlorates, and nitrates), since violent reactions occur. Storein tightly closed containers in a cool, well-ventilated area.Protect storage containers from physical damage. Sourcesof ignition, such as smoking and open flames, are prohibited where Butyl ether is handled, used, or stored. Metalcontainers involving the transfer of 5 gallons or more ofbutyl ether should be grounded and bonded. Drums must beequipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofButyl ether. | [Purification Methods]
Peroxides (detected by the liberation of iodine from weakly acid HCl solutions of 2% KI) can be removed by shaking 1L of ether with 5-10mL of a solution comprising of 6.0g of ferrous sulfate and 6mL conc H2SO4 and 110mL of water, with aqueous Na2SO3, or with acidified NaI, water, then aqueous Na2S2O3. After washing with dilute NaOH, KOH, or Na2CO3, then water, the ether is dried with CaCl2 and distilled. It can be further dried by distillation from CaH2 or Na (after drying with P2O5), and stored in the dark with Na or NaH. The ether can also be purified by treating with CS2 and NaOH, expelling the excess sulfide by heating. The ether is then washed with water, dried with NaOH and distilled [Kusama & Koike J Chem Soc Jpn, Pure Chem Sect 72 229 1951]. Other purification procedures include passage through an activated alumina column to remove peroxides, or through a column of silica gel, and distillation after adding about 3% (v/v) of a 1M solution of MeMgI in n-butyl ether. [Beilstein 1 IV 1520.] | [Toxicity evaluation]
Production of butyl ether and its use as an extracting agent
and a solvent may result in its release to the environment
through various waste streams. If released to air, a vapor
pressure of 6.0 mmHg at 25°C indicates that butyl ether will
exist solely as a vapor in the ambient atmosphere. Vaporphase
butyl ether reacts in the atmosphere with hydroxyl
radicals; the half-life for this reaction in air has been estimated
to be 13 h. Direct photolysis is not expected to be an
important removal process since aliphatic ethers do not
absorb light in the environmental spectrum. If released to
soil, butyl ether is expected to have high mobility based on
its estimated adsorption coefficient (Koc) of 51. Volatilization
from moist soil surfaces may be an important fate process
based on its reported Henry’s law constant of
6.0×10-3 atm m3 mol-1. Butyl ether is expected to volatilize
from dry soil surfaces based on its reported vapor
pressure. If released into water, butyl ether is not expected to
adsorb to suspended solids and sediment in water based on
its Koc. Aqueous screening studies indicate biodegradation
may be an important fate process in both soil and water; for
example, butyl ether reached 3–4% of its theoretical biological
oxygen demand (BOD) over 4 weeks using an activated
sludge seed. Volatilization from water surfaces is
expected to occur based on this compound’s estimated
Henry’s law constant. Estimated volatilization half-lives for
a model river and model lake have been reported to be 3.5 h
and 4.6 days, respectively. Bioconcentration factors (BCFs)
ranging from 30 to 114 in carp suggest that bioconcentration
in aquatic organisms is moderate to high. Butyl ether is not
expected to undergo hydrolysis in the environment due to
the lack of hydrolyzable functional groups. | [Incompatibilities]
Forms explosive mixture with air. Mayaccumulate static electrical charges, and may cause ignitionof its vapors. Incompatible with strong acids and oxidizers.Contact with air or light may form unstable and explosiveperoxides, especially anhydrous form. |
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