| Identification | More | [Name]
Climbazole | [CAS]
38083-17-9 | [Synonyms]
1-(4-CHLOROPHENOXY)-1-(1 H-IMIDAZOL-1-YL)-3,3-DIMETHYLBUTANONE
1-(4-CHLOROPHENOXY)-1-(IMIDAZOL-1-YL)-3,3-DIMETHYL-2-BUTANONE
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
BAYSAN
CLIMBAZOL
CLIMBAZOLE
1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one
1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone
1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanon
1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-Butanone
bay-e6975
baypival
RadixAsteris
1-(4-Chloro-phenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one
CLIMBAZOL PESTANAL 250 MG
CLIMBAZOL PESTANAL
1-(4-Chlorophenoxy)-3,3-dimethyl-1-imidazole-1-yl)-2-butone
1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-
climbazole (ban) | [EINECS(EC#)]
253-775-4 | [Molecular Formula]
C15H17ClN2O2 | [MDL Number]
MFCD00055505 | [Molecular Weight]
292.76 | [MOL File]
38083-17-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
96-100°C | [Boiling point ]
447.5±40.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [vapor pressure ]
0.001Pa at 25℃ | [refractive index ]
1.54 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Insoluble in water | [form ]
neat | [pka]
5.66±0.22(Predicted) | [color ]
White to Almost white | [Water Solubility ]
58mg/L at 25℃ | [BRN ]
618020 | [InChIKey]
OWEGWHBOCFMBLP-UHFFFAOYSA-N | [LogP]
3.83 at 25℃ | [CAS DataBase Reference]
38083-17-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 | [WGK Germany ]
3 | [RTECS ]
EL7085000 | [HS Code ]
29332900 |
| Questions And Answer | Back Directory | [Risks to the environment]
Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms. |
| Hazard Information | Back Directory | [Hazard]
Moderately toxic by ingestion. Low toxicity by skin contact. | [Description]
(±)-Climbazole is an imidazole antifungal agent.1 It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro.2,3,4 It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.1 (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.5 Formulations containing climbazole have been used in the treatment of dandruff. | [Chemical Properties]
White Solid | [Uses]
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix.
s assay and did not induce micronuclei in human lymphocytes. | [Definition]
ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether. | [Flammability and Explosibility]
Nonflammable | [Side effects]
May cause localized irritation of the skin with symptoms including redness, rashes and itching.
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