Neomycin, Sulfat (Salz) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation. It is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections.
Chemische Eigenschaften
White or yellowish-white powder; odorless; highly hygroscopic; aqueous
solution exhibits dextrorotation. High solubility in water, while almost
insoluble in ethanol, ether, acetone or chloroform.
Verwenden
Neomycin sulfate is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.
Indications
This drug is obtained from species of the actinomycete Streptomyces
and is an aminoglycoside antibiotic (as are streptomycin, gentamicin, and
kanamycin) effective against most aerobic gram-negative organisms. Group A streptococci
are relatively resistant. Neomycin acts to inhibit bacterial protein synthesis
by irreversibly binding to the 30S subunit. It is responsible for a greater incidence
of allergic contact sensitivity than any other topical antibiotic. This diagnosis often
remains hidden, because morphologically the eruption is of a mild eczematous
nature. Rarely, anaphylaxis may occur.
Weltgesundheitsorganisation (WHO)
Neomycin sulfate, a broad-spectrum antibiotic, was first isolated in 1949 and has subsequently been included in topical, oral and parenteral preparations. Its value in the treatment of diarrhoea is widely questioned although it is still contained in a number of widely available antidiarrhoeal preparations. In some countries the officially approved indications for oral preparations are restricted to the preparation of the bowel prior to surgery and the management of hepatic coma.
Allgemeine Beschreibung
Chemical structure: aminoglycoside
Kontakt-Allergie
Neomycin is an antibiotic complex of the aminoglycosides
group, extracted from Streptomyces fradiae. It is composed
of neomycin A (neamin) and an isomer neobiosamin, either neomycin B (framycetin or Soframycin?) or neomycin C.
Its use has been progressively forbidden in cosmetics and
as an additive for animal feed. Occupational contact dermatitis
occurs in workers at animal feed mills, in veterinaries,
or in health workers. Nonoccupational dermatitis mainly
concerns patients with chronic dermatitis, leg ulcers, or
chronic otitis. Cross-sensitivity is usual with other aminoglycosides
(amikacin, arbekacin, butirosin, dibekacin, gentamicin,
isepamicin, kanamycin, paromomycin,
ribostamycin, sisomycin, tobramycin), is rare with netilmicin
and streptomycin, but nonexistent with spectinomycin.
Clinical Use
In a search for antibiotics less toxic than streptomycin,Waksman and Lechevalier isolated neomycin (Mycifradin,Neobiotic) in 1949 from Streptomyces fradiae. Since then, theimportance of neomycin has increased steadily, and today, itis considered one of the most useful antibiotics for the treatmentof GI infections, dermatological infections, and acutebacterial peritonitis. Also, it is used in abdominal surgery toreduce or avoid complications caused by infections from bacterialflora of the bowel. It has broad-spectrum activityagainst various organisms and shows a low incidence of toxicand hypersensitivity reactions. It is absorbed very slightlyfrom the digestive tract, so its oral use ordinarily does not produce any systemic effect. The development of neomycinresistantstrains of pathogens is rarely reported in those organismsagainst which neomycin is effective.
Neomycin as the sulfate salt is a white to slightly yellow,crystalline powder that is very soluble in water. It is hygroscopicand photosensitive (but stable over a wide pH rangeand to autoclaving). Neomycin sulfate contains the equivalentof 60% of the free base.
Neomycin, as produced by S. fradiae, is a mixture ofclosely related substances. Included in the “neomycin complex”is neamine (originally designated neomycin A) andneomycins B and C. S. fradiae also elaborates another antibiotic,the fradicin, which has some antifungal propertiesbut no antibacterial activity. This substance is not present in“pure” neomycin.
Nebenwirkungen
The most common adverse reactions to oral neomycin sulfate are nausea, vomiting and diarrhea. The “Malabsorption Syndrome” characterized by increased fecal fat, decreased serum carotene and fall in xylose absorption has been reported with prolonged therapy.
Sicherheitsprofil
Poison by
intramuscular, intravenous, and
subcutaneous routes. Human systemic
effects by ingestion: somnolence,
hallucinations and distorted perceptions, and
anorexia. A human skin irritant. When
heated to decomposition it emits very toxic
fumes of SOx.
Neomycin, Sulfat (Salz) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
