Orlistat
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- CAS-Nr.
- 96829-58-2
- Englisch Name:
- Orlistat
- Synonyma:
- Orlistate;XENICAL;Orlistat Powder;aolisita;Orlipastat, Orlistat;N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER;(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER;Alisit;CS-836;oristat
- CBNumber:
- CB2431985
- Summenformel:
- C29H53NO5
- Molgewicht:
- 495.73
- MOL-Datei:
- 96829-58-2.mol
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Orlistat Eigenschaften
- Schmelzpunkt:
- <50 °C
- Siedepunkt:
- 615.9±30.0 °C(Predicted)
- alpha
- D20 -32.0° (c = 1 in chloroform)
- Dichte
- 0.976±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: 19 mg/mL
- Aggregatzustand
- solid
- pka
- 14.59±0.23(Predicted)
- Farbe
- white
- Merck
- 14,6869
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- AHLBNYSZXLDEJQ-FWEHEUNISA-N
- SMILES
- C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O
- CAS Datenbank
- 96829-58-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H412 |
Schädlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Orlistat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Orlistat was launched in the UK as Xenical for the long-term treatment
of obesity, preferably in conjunction with a moderately reduced calorie diet.
Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from
Streptomyces toxyfncini) and can be obtained either by hydrogenation of
lipstatine or by several different synthetic ways involving many steps from ( S ) -
rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the
lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a
result, it prevents the absorption of about one third of the fat contained in food
and acts as an effective weight-reducing therapy. The outcomes of several
clinical trials involving thousands of obese patients showed that Orlistat
promotes a significant weight loss (often between 5 and 10% after one year) and
improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio,
blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic
absorption, the majority of the compound itself being recovered in the feces ; it
does not affect other gastrointestinal processes, or the absorption of other
rnacronutrients such as carbohydrates and proteins.
Chemische Eigenschaften
Off-White Solid
Verwenden
Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by
Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.
Biologische Aktivität
Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .
Orlistat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Orlistat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 731)Lieferanten
96829-58-2()Verwandte Suche:
- RO-18-0647
- (-)-TETRAHYDROLIPSTATIN
- ORLISTAT
- Orlistat(synthesis)
- Orlistat(FerMentation)
- S,S,S,S-Orlistat
- (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-forMaMido-4-Methylpentanoate
- oristat
- N-formyl-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester L-Leucine
- Orlistat
N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
- Orlistat, >=98%
- Olistat
- Lipase Inhibitor, THL
- HY-B0218
- Orlipastat
- Orlistat,()-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
- Orlistat (200 mg)
- ORLISTAT (BULK MATERIAL)
- ORLISTAT PELLETS 50%
- (-)-Tetrahydrolipstatin(EquivalentToOrlistat)
- Xenical, (-)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester,
- Orlistat, Tetrahydolipstat
- ORLIPASTATUM
- Ro 18-0647/002
- (-)-Tetrahydrolipstatin, Ro-18-0647, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
- L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
- N-Formyl-L-leucine (1S)-1-[[(2S)-3α-hexyl-4-oxooxetan-2β-yl]methyl]dodecyl ester
- N-Formyl-L-leucine (S)-1-[[(2S)-3α-hexyl-4-oxooxetane-2β-yl]methyl]dodecyl ester
- Orlistat(synthetase/compound)
- Orlistat, 97%, General lipase inhibitor
- Alisit
- Orlistat Weight Loss Steroids
- Western wuming
- CS-836
- Orlistat Tablets
- Orlistat Orlistat
- Orlistat>
- Qrlistat
- (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate
- Orlistat Solution in Acetonitrile, 1000 ug/ml
- Orlistat powder for lose weight
- Orlista
- hot selling Orlistat
- ORLISTAT PALLET
- Orlistat USP/EP/BP
- Horse meriton
- Orlistat Impurity 29
- Xenical Orlistat
- Orlistat (Tetrahydrolipstatin)
- Prompt Delivery
- Orlistat D7Q: What is
Orlistat D7 Q: What is the CAS Number of
Orlistat D7 Q: What is the storage condition of
Orlistat D7 Q: What are the applications of
Orlistat D7
- OrlistatQ: What is
Orlistat Q: What is the CAS Number of
Orlistat Q: What is the storage condition of
Orlistat Q: What are the applications of
Orlistat
- Orlistat (1478800)
- (S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER
- N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER
- Orlipastat, Orlistat
- Orlistat Powder
- XENICAL
