Clotrimazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-
α demethylase isoform B from
A. fumigatus (K
D = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-
dependent potassium channels K
v1.3 and IK-
1 (IC
50 = 6.0 and 0.07 μM, respectively).
Chemische Eigenschaften
White or pale yellow, crystalline powder.
Verwenden
Clotrimazole is an antifungal agent.
Definition
ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Indications
Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a
broad-spectrum fungistatic imidazole drug used in the
topical treatment of oral, skin, and vaginal infections
with C. albicans. It is also employed in the treatment of
infections with cutaneous dermatophytes.
Topical use results in therapeutic drug concentrations
in the epidermis and mucous membranes; less
than 10% of the drug is systemically absorbed. Although
clotrimazole is generally well tolerated, local abdominal
cramping, increased urination, and transient
liver enzyme elevations have been reported.
Allgemeine Beschreibung
Chemical structure: imidazole
Clinical Use
1-(o-Chloro-α,α-diphenylbenzyl)imidazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum antifungal drug thatis used topically for the treatment of tinea infections and candidiasis.It occurs as a white crystalline solid that is sparinglysoluble in water but soluble in alcohol and most organic solvents.It is a weak base that can be solubilized by dilute mineralacids.
Clotrimazole is available as a solution in polyethyleneglycol 400, a lotion, and a cream in a concentration of 1%.These are all indicated for the treatment of tinea pedis, tineacruris, tinea capitis, tinea versicolor, or cutaneous candidiasis.A 1% vaginal cream and tablets of 100 mg and 500 mgare available for vulvovaginal candidiasis. Clotrimazole isextremely stable, with a shelf life of more than 5 years.
Clotrimazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
