ChemicalBook >> CAS DataBase List >>Propranolol Hcl
Propranolol Hcl
- CAS No.
- 318-98-9
- Chemical Name:
- Propranolol Hcl
- Synonyms
- PROPRANOLOL HCL;inderal;inderol;anaprilin;Dibudinate;InnoPran XL;kemi;Nedis;Ikopal;Herzul
- CBNumber:
- CB00128713
- Molecular Formula:
- C16H22ClNO2
- Molecular Weight:
- 295.8
- MDL Number:
- MFCD00012558
- MOL File:
- 318-98-9.mol
Last updated:2024-04-19 20:05:26
| Melting point | 163-165 °C(lit.) |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | powder |
| color | white |
| Water Solubility | SOLUBLE |
| Merck | 14,7840 |
| BRN | 4164259 |
| BCS Class | 1 |
| InChIKey | ZMRUPTIKESYGQW-UHFFFAOYSA-N |
| CAS DataBase Reference | 318-98-9(CAS DataBase Reference) |
| FDA UNII | F8A3652H1V |
| NCI Dictionary of Cancer Terms | Inderal; propranolol hydrochloride |
| NCI Drug Dictionary | Inderal |
| EPA Substance Registry System | Propranolol hydrochloride (318-98-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UB7525000 | |||||||||
| F | 10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29221990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee) | |||||||||
| NFPA 704 |
|
Propranolol Hcl price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P-055 | Propranolol hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 318-98-9 | 1mL | $36.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 40543 | (±)-Propranolol hydrochloride analytical standard | 318-98-9 | 100mg | $83.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1576005 | Propranolol hydrochloride United States Pharmacopeia (USP) Reference Standard | 318-98-9 | 200mg | $436 | 2024-03-01 | Buy |
| Alfa Aesar | H26645 | (±)-Propranolol hydrochloride, 99% | 318-98-9 | 5g | $82.4 | 2024-03-01 | Buy |
| Alfa Aesar | H26645 | (±)-Propranolol hydrochloride, 99% | 318-98-9 | 25g | $257 | 2024-03-01 | Buy |
Propranolol Hcl Chemical Properties,Uses,Production
Description
Propranolol hydrochloride is a off-white to light-yellow cyrstalline solid, easily soluble in ethanol and water.
Uses
Propranolol Hcl is a beta blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. It is also used to prevent migraine headaches and chest pain (angina).
Brand name
Inderal,Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Indoblok,Sumial, Anaprilin, and Bedranol SR (Sandoz),Ciplar,Ciplar LA
Mechanism of action
Propranolol is classified as a competitive non-cardioselective sympatholytic beta blocker that crosses the blood–brain barrier. It is lipid soluble and also has sodium channel blocking effects. Propranolol is a non-selective β-adrenergic receptor antagonist, or beta blocker.Propranolol is able to cross the blood–brain barrier and exert effects in the central nervous system in addition to its peripheral activity.
Pharmacokinetics
Propranolol Hcl is rapidly and completely absorbed, with peak plasma levels achieved about 1–3 hours after ingestion. More than 90% of the drug is found bound to plasma protein in the blood.Coadministration with food appears to enhance bioavailability.Despite complete absorption, propranolol has a variable bioavailability due to extensive first-pass metabolism. Hepatic impairment therefore increases its bioavailability. The main metabolite 4-hydroxypropranolol, with a longer half-life (5.2–7.5 hours) than the parent compound (3–4 hours), is also pharmacologically active. Most of the metabolites are excreted in the urine.
Side effects
Common side effects include nausea, abdominal pain, and constipation.It may worsen the symptoms of asthma.Propranolol may cause harmful effects for the baby if taken during pregnancy.
Propranolol Hcl Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 478)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16805 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Propranolol Hcl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Propranolol
525-66-6
|
US $0.00 / kg | 1kg | 99% | 20tons | Sinoway Industrial co., ltd. | |
 |
2021-07-13 | Propranolol hydrochloride
318-98-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-10 | R(+)-PROPRANOLOL HCL
5051-22-9
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Propranolol
525-66-6
- US $0.00 / kg
- 99%
- Sinoway Industrial co., ltd.
-
- Propranolol hydrochloride
318-98-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- R(+)-PROPRANOLOL HCL
5051-22-9
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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(+/-)-PROPRANOLOL HYDROCHLORIDE
PROPRANOLOL HYDROCHLORIDE
(+/-)-PROPANOLOL HCL
PROPANOLOL HYDROCHLORIDE
DL-Propranolol hydrochloride, 99% 5GR
Propranolol Hydrochloride (200 mg)
rac-Propranolol Hydrochloride
ici45520
inderalhydrochloride
nsc-91523
2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:1)
Propranolol hydrochloride Solution, 100ppm
Propranolol Solution
1-(isopropylaMino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
Cardinol
Corbeta
1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanohydrochloride
1-(1-naphthyloxy)-2-hydroxy-3-isopropylaminopropanehydrochloride
1-(isopropylamino)-3-(1-naphthyloxy)-2-propanohydrochloride
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-olhydrochloride
1-(isopropylamino)-3-(alpha-naphthoxy)-2-propanolhydrochloride
1-isopropylamino-3-(1-naphthoxy)-propan-2-ol-hydrochloride
ay64043
DL-PROPRANOLOL HYDROCHLORIDE 99%
1-(ISOPROPYLAMINO)-3-(A-NAPHTHOXY)-2-PROPANOL HYDROCHLORIDE
(+)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, HCL
(+/-)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, HCL
(+/-)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
1-[ISOPROPYLAMINO]-3-[1-NAPHTHYLOXY]-2-PROPANOL HYDROCHLORIDE
DL-PROPRANOLOL HYDROCHLORIDE
DL-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
AURORA KA-6762
1[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol Hydrochloride
Bedranol
Beta-Tablinen
NCS-91523
2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride
PROPRANOLOLHYDROCHLORIDE,USP
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride
PROPRANOLOL H+D409CL USP
1-[2-Hydroxy-3-(isopropylamino)propoxy]naphthalene
DL-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
Inderal LA
1-(1-Naphtyloxy)-3-(isopropylamino)-2-propanol·hydrochloride
Propranolol hydrochlotide
DL-Propranolol hydrochloride,99%
Propranolol Hydrochloride For Performanc
Propranolol hydrochloride 318-98-9
Propranolol hydrochloride CRS
Propranolol hydrochloride for performance test CRS
Propranolol in Methanol
Propranolol hydrochloride USP/EP/BP
Propranolol HCl (AY64043, ICI45520, NCS91523)
Propranolol hydrochloride (P3500000)Q: What is
Propranolol hydrochloride (P3500000) Q: What is the CAS Number of
Propranolol hydrochloride (P3500000) Q: What are the applications of
Propranolol hydrochloride (P3500000)
Propranolol Hydrochloride (1576005)
PropranoL
hydrochL