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Ibudilast

CAS No. 50847-11-5
Chemical Name: Ibudilast
Synonyms: Ketas;KC-404;AV 411;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast;IBUDILAST-D7;Ibudilast, >=98%
CBNumber: CB0145945
Molecular Formula: C14H18N2O
Formula Weight: 230.31
MOL File: 50847-11-5.mol
Ibudilast Property
Melting point : 53-54°C
density : 1.09
storage temp. : 2-8°C
solubility : DMSO: 28 mg/mL, soluble
form : solid
color : white
CAS DataBase Reference: 50847-11-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn
Risk Statements : 22-36/37/38
Safety Statements : 26-36
WGK Germany : 3
RTECS : UR0711200
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Ibudilast Chemical Properties,Usage,Production

Chemical Properties
White Solid
Uses
a phosphodiesterase inhibitor with anti-inflammatory activity
Uses
A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
Uses
Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
Biological Activity
Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
Raw materials
Sodium acetate 2-Picoline Isobutyric anhydride
Preparation Products
Ibudilast Suppliers      Global( 137)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
GIHI CHEMICALS CO.,LTD 0086-571-86217390
0086-571-86217391 Sales@gihichem.com China 885 58
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197
010-68882204 bjhkby@126.com China 87 61
Shanghai Boyle Chemical Co., Ltd. 86-21-50180596
86-21-57758967 sales@boylechem.com China 2815 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6041 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22833 81
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15554 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44197 61
 
50847-11-5(Ibudilast)Related Search:
Ibudilast Bensulfuron methyl Citric acid monohydrate Parathion-methyl Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Methyl Methyl bromide Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE
Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides IBUDILAST IBUDILAST-D7 KC-404 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL] 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE BioChemical Cell Signaling and Neuroscience Cell Biology 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE 50847-11-5 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo( lbudilast 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas Intermediates & Fine Chemicals Pharmaceuticals 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone Cyclic Nucleotide related 3-Isobutyryl-2-isopropy-lpyrazolo[1,5-α]pyridine Ketas Eyevinal 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone Pinatos Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404 Amines Heterocycles 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one AV 411 Ibudilast (KC-404) Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one Ibudilast, >=98% Inhibitors budilast 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]
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