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CAS No.50847-11-5
Chemical Name:Ibudilast
Synonyms:Ketas;KC-404;AV 411;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast;IBUDILAST-D7;Ibudilast, >=98%
Molecular Formula:C14H18N2O
Formula Weight:230.31
MOL File:50847-11-5.mol
Ibudilast Property
Melting point : 53-54°C
density : 1.09
storage temp. : 2-8°C
solubility : DMSO: 28 mg/mL, soluble
form : solid
color : white
CAS DataBase Reference: 50847-11-5(CAS DataBase Reference)
Hazard Codes : Xn
Risk Statements : 22-36/37/38
Safety Statements : 26-36
WGK Germany : 3
RTECS : UR0711200

Ibudilast Chemical Properties,Usage,Production

Chemical Properties
White Solid
a phosphodiesterase inhibitor with anti-inflammatory activity
A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
Biological Activity
Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
Raw materials
Sodium acetate 2-Picoline Isobutyric anhydride
Preparation Products
Ibudilast Suppliers      Global( 135)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
GIHI CHEMICALS CO.,LTD 0086-571-86217390 China 885 58
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197 China 87 61
Shanghai Boyle Chemical Co., Ltd. 86-21-50180596 China 2790 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833; China 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037 China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0); China 6042 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390 China 22833 81
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057; China 15555 55
Energy Chemical 021-58432009 / 400-005-6266 China 44198 61
50847-11-5(Ibudilast)Related Search:
Ibudilast Bensulfuron methyl Citric acid monohydrate Parathion-methyl Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Methyl Methyl bromide Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE
Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides IBUDILAST IBUDILAST-D7 KC-404 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL] 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE BioChemical Cell Signaling and Neuroscience Cell Biology 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE 50847-11-5 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo( lbudilast 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas Intermediates & Fine Chemicals Pharmaceuticals 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone Cyclic Nucleotide related 3-Isobutyryl-2-isopropy-lpyrazolo[1,5-α]pyridine Ketas Eyevinal 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone Pinatos Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404 Amines Heterocycles 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one AV 411 Ibudilast (KC-404) Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one Ibudilast, >=98% Inhibitors budilast
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