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Ibudilast

Ibudilast
Ibudilast
CAS No.
50847-11-5
Chemical Name:
Ibudilast
Synonyms
Ketas;KC-404;AV 411;Pinatos;budilast;Eyevinal;IBUDILAST;lbudilast;IBUDILAST-D7;Ibudilast, >=98%
CBNumber:
CB0145945
Molecular Formula:
C14H18N2O
Formula Weight:
230.31
MOL File:
50847-11-5.mol

Ibudilast Properties

Melting point:
53-54°C
Density 
1.09
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
color 
white
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UR0711200
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Ibudilast price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 10mg $229 2017-11-08 Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 50mg $879 2017-11-08 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 20mg $128 2017-11-08 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 100mg $430 2017-11-08 Buy
Cayman Chemical 14832 Ibudilast ≥98% 50847-11-5 1mg $25 2017-11-08 Buy

Ibudilast Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products


Ibudilast Suppliers

Global( 139)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
GIHI CHEMICALS CO.,LTD 0086-571-86217390
0086-571-86217391 Sales@gihichem.com China 885 58
Shandong Chenxi Pharmaceutical Co., Ltd. 0531-88803416 13153166250
0531-88803416 sales@chemedpharma.com CHINA 122 58
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197
010-68882204 bjhkby@126.com China 87 61
Shanghai Boyle Chemical Co., Ltd. 86-15221043597
86-21-57758967 sales@boylechem.com China 2849 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6035 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22833 81
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15554 55

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