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Calcitriol

Introduction References
Calcitriol
Calcitriol
CAS No.
32222-06-3
Chemical Name:
Calcitriol
Synonyms
Silkis;ro215535;Calcijex;Soltriol;Toptriol;Panbonis;1,25-dhcc;rocaltrol;Topitriol;CALCITROL
CBNumber:
CB0171027
Molecular Formula:
C27H44O3
Formula Weight:
416.64
MOL File:
32222-06-3.mol

Calcitriol Properties

Melting point:
119-1210C
alpha 
D25 +48° (methanol)
Flash point:
14 °C
storage temp. 
2-8°C
solubility 
Do you have solubility information on this product that you would like to share
λmax
265nm(lit.)
Merck 
14,1644
Stability:
Air and Light Sensitive
InChIKey
GMRQFYUYWCNGIN-UNVJKIGWSA-N
CAS DataBase Reference
32222-06-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,Xn,F
Risk Statements  26/27/28-63-36/37/38-20/21/22-11
Safety Statements  36/37/39-45-36-26-16-7
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  FZ4645000
8-10-19
HazardClass  6.1(a)
PackingGroup  I
HS Code  29061900
Hazardous Substances Data 32222-06-3(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Calcitriol price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1086312 Calcitriol solution United States Pharmacopeia (USP) Reference Standard 32222-06-3 5ml $431.3 2017-11-08 Buy
Sigma-Aldrich 17936 1α,25-Dihydroxyvitamin D3 ≥97.0% (HPLC) 32222-06-3 1mg-f $1345 2017-11-08 Buy
TCI Chemical C3078 Calcitriol >97.0%(HPLC) 32222-06-3 1mg $564 2017-12-01 Buy
Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 1mg $68 2017-11-08 Buy
Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 5mg $255 2017-11-08 Buy

Calcitriol Chemical Properties,Uses,Production

Introduction

Calcitriol (1,25-dihydroxylcholecaldiferol) is a steroid hormone with three hydroxyl groups, which is an active metabolite and the most effective form of vitamin D. It is produced primarily in the kidney when the blood calcium level and parathyroid hormone are low. Calcitriol promotes the calcium and phosphorus absorption in the intestine, reabsorption in the kidneys. Along with parathyroid hormone, it regulates bone growth for building and keeping strong bones. Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally, to treat secondary hyperparathyroidism and metabolic bone disease in people with kidney disease. Calcitriol may also be chemopreventive for colon and prostate cancers as it induces cell cycle arrest, cell differentiation, and apoptosis.

References

  1. https://pubchem.ncbi.nlm.nih.gov
  2. https://medlineplus.gov
  3. http://flexikon.doccheck.com/en/Calcitriol
  4. https://en.wikipedia.org/wiki/Calcitriol
  5. https://www.webmd.com

Description

Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemical Properties

White Crystalline Powder

Uses

Calcium regulator, anti-psoriatic

Uses

Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

Uses

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

Definition

ChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.

Uses

Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]

Biological Activity

Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Calcitriol Preparation Products And Raw materials

Raw materials

Preparation Products


Calcitriol Suppliers

Global( 228)Suppliers
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Dishman Netherlands B.V.
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Capot Chemical Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
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Chemvon Biotechnology Co., Ltd +86-21-50790412
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Haoyuan Chemexpress Co., Ltd. 86-21-58998985
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Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
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Hydragon Pharma Ltd +86(21)5021-5258, 5021-8972
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Jiangxi fluopharm chemicals co.,ltd 13916493875/021-52217929 ,18779577211/0795-2519299
QQ:2065104902 sales@fluopharm.com rita.liu@fluopharm.com China 45 58
Zhengzhou Kangshan Biological Co., Ltd. 17724848962 QQ:2584787837
0371-55616640 947309153@qq.com China 31 58
Shanghai Boyle Chemical Co., Ltd. 86-15221043597
86-21-57758967 sales@boylechem.com China 2861 55

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