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Calcitriol

CAS No. 32222-06-3
Chemical Name: Calcitriol
Synonyms: Silkis;ro215535;Calcijex;Soltriol;Toptriol;Panbonis;1,25-dhcc;rocaltrol;Topitriol;CALCITROL
CBNumber: CB0171027
Molecular Formula: C27H44O3
Formula Weight: 416.64
MOL File: 32222-06-3.mol
Calcitriol Property
Melting point : 119-1210C
Fp : 14 °C
storage temp. : 2-8°C
solubility : Do you have solubility information on this product that you would like to share
Stability:: Air and Light Sensitive
CAS DataBase Reference: 32222-06-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T+,Xn,F
Risk Statements : 26/27/28-63-36/37/38-20/21/22-11
Safety Statements : 36/37/39-45-36-26-16-7
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS : FZ4645000
F : 8-10-19
HazardClass : 6.1(a)
PackingGroup : I
HS Code : 29061900
Hazardous Substances Data: 32222-06-3(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Calcitriol Chemical Properties,Usage,Production

Description
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.
Chemical Properties
White Crystalline Powder
Uses
Calcium regulator, anti-psoriatic
Uses
Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;
Uses
The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic
Definition
ChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Uses
Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]
Biological Activity
Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Calcitriol Preparation Products And Raw materials
Raw materials
Preparation Products
Calcitriol Suppliers      Global( 220)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Chemvon Biotechnology Co., Ltd +86-21-50790412
+86-21-50790419 marketing@chemvon.com China 331 57
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 8181 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9946 62
Hydragon Pharma Ltd +86(21)5021-5258, 5021-8972
+86(21)5021-5756 market@hypharma.com China 321 58
Jiangxi fluopharm chemicals co.,ltd 13916493875/021-52217929 ,18779577211/0795-2519299
QQ:2065104902 sales@fluopharm.com rita.liu@fluopharm.com China 45 58
Shanghai Boyle Chemical Co., Ltd. 86-21-50180596
86-21-57758967 sales@boylechem.com China 2836 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6041 61
 
32222-06-3(Calcitriol)Related Search:
SB216763 Bortezomib Bosutinib 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Dasatinib Crizotinib VITAMIN D3 FALECALCITRIOL Calcitriol AURORA KA-6724 1ALPHA,25-DIHYDROXY[23,24(N)-3H]-CHOLECALCIFEROL 1ALPHA,25-DIHYDROXY[26,27-METHYL-3H]-CHOLECALCIFEROL
VITAMIN D3, 1ALPHA,25-DIHYDROXY (5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol 9,10-SECOCHOLESTA-5Z,7E,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL 32222-06-3 1,25-(OH)2-D3 (1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL 1ALPHA,25-DIHYDROXYCHOLECALCIFEROL 1ALPHA,25-DIHYDROXYVITAMIN D3 1ALPHA,25-DIHYDROXY-VITAMIN D8 1A, 25-DIHYDROXYCHOLECALCIFEROL CALCITRIOL (5z,7e)-9,10-secochesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol (5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol 1,25-dhcc 1,25-dihydroxycholecalciferol 1,25-dihydroxyvitamind 1a,25-dihydroxy-cholecalcifero 1-alpha,25-dihydroxy-cholecalcifero 7,10(19)-triene-1,3,25-triol,(1-alpha,3-beta,5z,7e)-10-secocholesta-5 7,10(19)-triene-1,3,25-triol,(1alpha,3beta,5z,7e)-10-secocholesta-5 9,10seco(5z,7e)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol dihydroxyvitamind3 ro215535 rocaltrol 1a,25-Dihydroxyvitamin Vitamin D3, 1a,25-Dihydroxy- CALCITRIOL USP C27H44O3 1α,25-Dihydroxyvitamin D3 (1a,3b,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, Calcijex Silkis Soltriol Topitriol Toptriol 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1.alpha.,3.beta.,5Z,7E)- 3222-06-3 (1R,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol CALCITRIOL(RG) 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1α,3β,5Z,7E)- 1,25-DIHYROXYCHOLECALIFEROL 1ALPHA,25-DIHYDROXYVITAMIND 1,25-DIHYDROXYCHOLECALIFEROL 1,25-VITAMIND 1,25-DIHYDROXYCHOLESCALIFEROL Miscellaneous Biochemicals Vitamin D3 analogs CALCITROL API CALCITRIOL (1α,25-DIHYDROXY VITAMIN D3) 5-{2-[1-(5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol(1,25-Dihydroxyvitamin D3, Calcitriol) (1a,3,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1a,3b,5Z,7E)- 1alpha,25-Dihy 25-dihydroxycholecalciferol
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