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Calcitriol

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Calcitriol Basic information
Physiological function Uses Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage characteristics Extinguishing agent
Product Name:Calcitriol
Synonyms:VITAMIN D3, 1ALPHA,25-DIHYDROXY;(5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;9,10-SECOCHOLESTA-5Z,7E,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL;1,25-(OH)2-D3;(1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL;1ALPHA,25-DIHYDROXYCHOLECALCIFEROL;1ALPHA,25-DIHYDROXYVITAMIN D3;1ALPHA,25-DIHYDROXY-VITAMIN D8
CAS:32222-06-3
MF:C27H44O3
MW:416.64
EINECS:250-963-8
Product Categories:Miscellaneous Biochemicals;Vitamin D3 analogs;API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Isolabel;reagent;standard substance;Inhibitors
Mol File:32222-06-3.mol
Calcitriol Structure
Calcitriol Chemical Properties
mp 119-1210C
Fp 14 °C
storage temp. 2-8°C
Stability:Air and Light Sensitive
CAS DataBase Reference32222-06-3(CAS DataBase Reference)
Safety Information
Hazard Codes T+,Xn,F
Risk Statements 26/27/28-63-36/37/38-20/21/22-11
Safety Statements 36/37/39-45-36-26-16-7
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS FZ4645000
8-10-19
HazardClass 6.1(a)
PackingGroup I
HS Code 29061900
Hazardous Substances Data32222-06-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
1alpha,25-Dihydroxycholecalciferol English
SigmaAldrich English
Calcitriol Usage And Synthesis
Physiological functionCalcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.
UsesVitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;
Categorytoxic substances
Toxicity gradinghighly toxic
Acute toxicityoral - rat LD50 0.62 mg / kg; Oral - Mouse LD50: 1.35 mg / kg
Flammability and hazard characteristicsflammable with the fire releasing acrid smoke
Storage characteristicsTreasury: ventilation, low-temperature and drying; store it separately from food
Extinguishing agentwater, sand
Chemical PropertiesWhite Crystalline Powder
UsageThe biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic
UsageCalcium regulator, anti-psoriatic
Biological ActivityActive metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Calcitriol Preparation Products And Raw materials
Tag:Calcitriol(32222-06-3) Related Product Information
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