ChemicalBook >> CAS DataBase List >>Oxobutanedioic acid

Oxobutanedioic acid

CAS No.
328-42-7
Chemical Name:
Oxobutanedioic acid
Synonyms
OXALOACETIC ACID;OXALACETIC ACID;2-OXOSUCCINIC ACID;OAA;oxalacetic;NSC 77688;NSC 284205;2-OXOSUCCINIC;OXLACETIC ACID;oxaloaceticaci
CBNumber:
CB0271682
Molecular Formula:
C4H4O5
Molecular Weight:
132.07
MDL Number:
MFCD00002592
MOL File:
328-42-7.mol
MSDS File:
SDS
Last updated:2023-09-13 17:49:43

Oxobutanedioic acid Properties

Melting point 161 °C (dec.)(lit.)
Boiling point 163.94°C (rough estimate)
Density 1.3067 (rough estimate)
vapor pressure 0.003Pa at 20℃
refractive index 1.4000 (estimate)
Flash point 88°C
storage temp. -20°C
solubility H2O: 100 mg/mL
form powder
pka 2.22(at 25℃)
color White to off-white
PH 3.05(1 mM solution);2.29(10 mM solution);1.68(100 mM solution)
Water Solubility soluble
Merck 14,6909
BRN 1705475
Stability Stable. Incompatible with strong oxidizing agents. Keep refrigerated.
LogP -1.04 at 20℃
CAS DataBase Reference 328-42-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 2F399MM81J
NIST Chemistry Reference Oxalacetic acid(328-42-7)
EPA Substance Registry System Oxalacetic acetic (328-42-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3261 8/PG 2
WGK Germany  3
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29183000
NFPA 704
1
3 0

Oxobutanedioic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O4126 Oxaloacetic acid ≥97% (HPLC) 328-42-7 1g $61.8 2024-03-01 Buy
TCI Chemical O0072 Oxalacetic Acid >97.0%(T) 328-42-7 5g $58 2024-03-01 Buy
TCI Chemical O0072 Oxalacetic Acid >97.0%(T) 328-42-7 25g $168 2024-03-01 Buy
Alfa Aesar 015789 Oxalacetic acid, 98+% 328-42-7 2g $31.65 2024-03-01 Buy
Alfa Aesar 015789 Oxalacetic acid, 98+% 328-42-7 10g $127 2023-06-20 Buy
Product number Packaging Price Buy
O4126 1g $61.8 Buy
O0072 5g $58 Buy
O0072 25g $168 Buy
015789 2g $31.65 Buy
015789 10g $127 Buy

Oxobutanedioic acid Chemical Properties,Uses,Production

Description

Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.

Chemical Properties

off-white crystals

Uses

Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.

Uses

Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is an intermediate in the citric acid cycle and glucogenesis.

Uses

A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.

Definition

ChEBI: An oxodicarboxylic acid that is succinic acid bearing a single oxo group.

General Description

Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.

Flammability and Explosibility

Not classified

Biological Activity

Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.

Biochem/physiol Actions

Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.

Purification Methods

Crystallise it from boiling EtOAc, or from hot Me2CO/hot *C6H6. [Beilstein 3 IV 1808.]

142-45-0
328-42-7
Synthesis of Oxobutanedioic acid from Acetylenedicarboxylic acid
Global( 278)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871 sales@ansciepchem.com CHINA 4242 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47464 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23396 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9340 58

View Lastest Price from Oxobutanedioic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Oxobutanedioic acid pictures 2023-11-01 Oxobutanedioic acid
328-42-7
US $0.00-0.00 / g 1g 98% 100kg Hangzhou ICH Biofarm Co., Ltd
Oxobutanedioic acid pictures 2023-09-13 Oxobutanedioic acid
328-42-7
US $100.00 / bag1 1bag1 99 5000 Hebei Fengqiang Trading Co., LTD
Oxobutanedioic acid pictures 2023-09-07 Oxobutanedioic acid
328-42-7
US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
OXOBUTANEDIOIC ACID OXOBUTANEDIOTIC ACID OXOSUCCINIC ACID OXLACETIC ACID OXALEACETIC ACID oxalacetic acid hybri-maxtm oxo-butanedioicaci Oxalacetic acid 2-Oxosuccinic OXALACETIC ACID, CELL CULTURE TESTED OXALACETIC ACID HYBRI-MAX OxalaceticAcid,~98% Ketosuccinic acid, Oxosuccinic acid 2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid 2-Ketosuccinic acid Butanedioic acid, oxo- 2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxaloacetic acid, Oxobutanedioic acid 2-Oxosuccinic acid, Oxobutanedioic acid KETOSUCCINIC ACID Oxalacetic acid,96% 2-OXOSUCCINIC NSC 284205 NSC 77688 Oxaloethanoic Acid Oxalacetic acid, 98% 5GR Butanedioic acid,2-oxo- Oxalacetic acid SynonyMs 2-Oxosuccinic acid Oxalacetic acid,cis form OXALOACETIC ACID, >=97% (HPLC) Oxaloacetic Acid - CAS 328-42-7 - Calbiochem OxalaceticAcid> Malic Acid Impurity 5 oxaloaceticaci Oxalacetic Acid for cell culture, 98% PRT062607 (P505-15 OXALACETIC ACID OXALOACETIC ACID OAA 2-OXOSUCCINIC ACID oxalacetic 328-42-7 HOOCCOCH2COOH C4H4O5 HOOCCH2COCOOH HO2CCH2COCO2H C1 to C5 Carboxylic Acids Carbonyl Compounds BioChemical Biochemicals and Reagents Building Blocks Enzymes, Inhibitors, and Substrates Enzyme Substrates Substrates by Enzyme Oxaloacetate decarboxylase Organic Building Blocks Metabolomics Metabolites and Cofactors on the Metabolic Pathways Chart Metabolic Pathways