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1-Methyl-4-pyrazole boronic acid pinacol ester

1-Methyl-4-pyrazole boronic acid pinacol ester structure

CAS No.: 761446-44-0

Chemical Name:: 1-Methyl-4-pyrazole boronic acid pinacol ester

Synonyms: 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy

CBNumber:: CB0414153

Molecular Formula:: C10H17BN2O2

Molecular Weight:: 208.07

MDL Number:: MFCD03789259

MOL File:: 761446-44-0.mol

Last updated:2024-01-03 13:33:01

Request For Quotation

1-Methyl-4-pyrazole boronic acid pinacol ester Properties

Melting point	59-64 °C(lit.)
Boiling point	308.3±15.0 °C(Predicted)
Density	1.05±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (slightly), Methanol (Slightly)
pka	2.09±0.10(Predicted)
form	Crystals
color	Off-white to yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey	UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES	N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference	761446-44-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Xn,F,Xi

Risk Statements

22-36/37/38

Safety Statements

26-36-37/39

WGK Germany

Hazard Note

Irritant/Flammable

TSCA

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
2		0

1-Methyl-4-pyrazole boronic acid pinacol ester price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	595314	1-Methylpyrazole-4-boronic acid pinacol ester 95%	761446-44-0	1g	$33.88	2024-03-01	Buy
Sigma-Aldrich	595314	1-Methylpyrazole-4-boronic acid pinacol ester 95%	761446-44-0	5g	$114.6	2024-03-01	Buy
TCI Chemical	M2339	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(GC)	761446-44-0	1g	$52	2024-03-01	Buy
TCI Chemical	M2339	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(GC)	761446-44-0	5g	$66	2024-03-01	Buy
Alfa Aesar	H53139	1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%	761446-44-0	1g	$108.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
595314	1g	$33.88	Buy
595314	5g	$114.6	Buy
M2339	1g	$52	Buy
M2339	5g	$66	Buy
H53139	1g	$108.65	Buy

1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Synthesis

To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

1-Methyl-4-pyrazole boronic acid pinacol ester synthesis

Synthesis of 1-Methyl-4-pyrazole boronic acid pinacol ester from 4-Pyrazoleboronic acid pinacol ester and Iodomethane

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Potassium hydroxide 4-Bromopyrazole Tetrahydrofuran

5A molecular sieve Methyl bromide Iodomethane n-Butyllithium 4-Iodo-1-methyl-1H-pyrazole

4-Bromo-1-methylpyrazole 4-Chloro-1-methylpyrazole 1-Methyl-1H-pyrazole-4-boronic acid 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic acid pinacol ester

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Preparation Products

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)Quinoxaline 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-pyrazole boronic acid pinacol ester Suppliers

Global( 415)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
China Synchem Technology Co.,Ltd.	+86-0552-4929304 +86-18055277008	wangxuhui1985@126.com	China	55	55
Lianhe Aigen Pharmatech Co.,Ltd.	+86-18918657159 +86-18918657159	sales-Aigen@lianhetech.com	China	305	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Zjartschem	+86-571-8723 8903 jocelynpan@zjarts.com	jocelynpan@zjarts.com	CHINA	993	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
China Synchem Technology Co.,Ltd.	55
Lianhe Aigen Pharmatech Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
career henan chemical co	58

View Lastest Price from 1-Methyl-4-pyrazole boronic acid pinacol ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-04	1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0	US $30.00-2.00 / kg	1kg	99	g-kg-tons,free sample is available	Henan Fengda Chemical Co., Ltd
2023-01-31	1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0	US $100.00 / kg	1kg	99	200tons	Hebei Mojin Biotechnology Co., Ltd
2023-01-31	1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
US $30.00-2.00 / kg
99
Henan Fengda Chemical Co., Ltd

1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
US $100.00 / kg
99
Hebei Mojin Biotechnology Co., Ltd

1-Methylpyrazole-4-boronic acid pinacol ester
761446-44-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

1-Methyl-4-pyrazole boronic acid pinacol ester Spectrum

1-Methyl-4-pyrazole boronic acid pinacol ester(761446-44-0)¹HNMR 1-Methyl-4-pyrazole boronic acid pinacol ester(761446-44-0)FT-IR

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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2- 1-METHYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TERAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-methyl-4-(4，4，5，5-tetramethyl-1，3，2-dioxaborolan-2-yl)-1H- 1-Methyl-4-pyrazoleboronic acid pinacol ester, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5-trimethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 2-(1-Methylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyrazole 1-Methyl-4-(4,4,5,5-Tetramethy 1-Methyl-4-Pyridineboronic acid pinacol ester 1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-Methylpyrazole-4-boronic acid pinacol ester 95% 1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-1H-pyrazole-4-boronic acid pinacol -Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan 3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1-Methyl-1H-pyrazol-4-ylboronate 1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-1H-PYRAZOLE 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ,95% 1-Methylpyrazole-4-boronic acid pinacol ester ,98% 1-Methylpyrazole-4-boroni... 1-Methyl-4-(4 1-Methy-4-(4,4,5,5,-tertamethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference) 1-MethylPyrazole-4-Boronic acid Pinacolate 2-(1-Methyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 99% 1-methyl-4-(4-tetramethyl-1-dioxaborolan-2-yl)-1H- 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole> e-4-boronic acid pinacoL (1-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole 1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER 1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER 1- methylpyrazole -4- boracic acid methyl alcohol ester Angelica oil 8015-64-3 Tranexamic Acid Impurity 27-13C2 761446-44-0 761446-18-6 76146-44-0 C10H17BN2O2 C10H19BN2O3 Boronate Esters Boronic Acids and Derivatives Chemical Synthesis Heteroaryl Boronate Esters Organometallic Reagents Heterocyclic Building Blocks Organoborons Pyrazole Boronic acid