Sitagliptin phosphate monohydrate
- CAS No.
- 654671-77-9
- Chemical Name:
- Sitagliptin phosphate monohydrate
- Synonyms
- Sitagliptin phosphate hydrate;Sitagliptin monohydrate;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Sitagliptin Phosphate.H2O;(R)-3-Amino-1-(3-(trifluor;itagliptin phosphate monohydrate;(R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;D06645
- CBNumber:
- CB11011754
- Molecular Formula:
- C16H18F6N5O5P
- Molecular Weight:
- 505.31
- MDL Number:
- MFCD10001393
- MOL File:
- 654671-77-9.mol
Flash point | 274.3℃ |
---|---|
storage temp. | 2-8°C |
solubility | ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic |
form | solid |
color | White to off-white |
InChIKey | IQFYVLUXQXSJJN-OVMXBOEKNA-N |
SMILES | P(O)(O)(O)=O.C(C1=NN=C2CN(C(=O)C[C@H](N)CC3C=C(F)C(F)=CC=3F)CCN12)(F)(F)F |&1:15,r| |
CAS DataBase Reference | 654671-77-9(CAS DataBase Reference) |
FDA UNII | TS63EW8X6F |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H319-H373 |
Precautionary statements | P260-P264-P280-P305+P351+P338-P314-P337+P313 |
Risk Statements | 28-38-41-48-62-63 |
Safety Statements | 24/25-26-28-36/37/39 |
HS Code | 29335990 |
Sitagliptin phosphate monohydrate price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR1857 | Sitagliptin Phosphate Pharmaceutical Secondary Standard; Certified Reference Material | 654671-77-9 | 1g | $173 | 2024-03-01 | Buy |
Sigma-Aldrich | 1612903 | Sitagliptin phosphate United States Pharmacopeia (USP) Reference Standard | 654671-77-9 | 200mg | $436 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001812 | Sitagliptin phosphate monohydrate EuropePharmacopoeia (EP) Reference Standard | 654671-77-9 | y0001812 | $220 | 2024-03-01 | Buy |
American Custom Chemicals Corporation | API0000800 | SITAGLIPTIN PHOSPHATE MONOHYDRATE 95.00% | 654671-77-9 | 1G | $918.23 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0000800 | SITAGLIPTIN PHOSPHATE MONOHYDRATE 95.00% | 654671-77-9 | 5G | $2246.48 | 2021-12-16 | Buy |
Sitagliptin phosphate monohydrate Chemical Properties,Uses,Production
Chemical Properties
white crystalline
Uses
antimuscarinic
Uses
Sitagliptin Phosphate Monohydrate is a dipeptidyl peptidase-IV (DPPIV) inhibitor.
Biological Activity
sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10.
target
DPP-4
Sitagliptin phosphate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
S&Y Biochem Co.,Ltd | +8617774091612 | marketing@sybiochem.com | China | 95 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5872 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | sales@zhswyy.com | China | 303 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 251 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
View Lastest Price from Sitagliptin phosphate monohydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Sitagliptin phosphate monohydrate
654671-77-9
|
US $0.00-0.00 / kg | 1kg | 99%, Single impurity<0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2024-09-20 | Sitagliptin phosphate monohydrate
654671-77-9
|
US $1.00 / kg | 1kg | 99 | 5000 | S&Y Biochem Co.,Ltd | ||
2024-09-20 | Sitagliptin Phosphate Monohydrate
654671-77-9
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
- Sitagliptin phosphate monohydrate
654671-77-9
- US $0.00-0.00 / kg
- 99%, Single impurity<0.1
- Nanjing Fred Technology Co., Ltd
- Sitagliptin phosphate monohydrate
654671-77-9
- US $1.00 / kg
- 99
- S&Y Biochem Co.,Ltd
- Sitagliptin Phosphate Monohydrate
654671-77-9
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.