Tenoxicam | 59804-37-4

Tenoxicam Properties

Melting point	209-2130C (dec)
Density	1.4737 (rough estimate)
refractive index	1.6390 (estimate)
storage temp.	2-8°C
solubility	Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.
pka	pKa1 5.3, pKa2 1.1(at 25℃)
color	White to Yellow to Green
Water Solubility	61.9mg/L(32 ºC)
CAS DataBase Reference	59804-37-4
EWG's Food Scores	1
FDA UNII	Z1R9N0A399
ATC code	M01AC02

Pharmacokinetic data

Protein binding	99%
Excreted unchanged in urine	<1 (67% as metabolites and unchanged drug)
Volume of distribution	10-12 Litres
Biological half-life	72 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301+H311+H331

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P311

Hazard Codes

T,Xi

Risk Statements

23/24/25-36/37/38

Safety Statements

36/37/39-45-36-26-36/37

RIDADR

UN 2811 6.1/PG 3

WGK Germany

2

RTECS

XJ9095060

HS Code

2934.99.3000

HazardClass

6.1

NFPA 704

	0
4		0

Tenoxicam price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T0909	Tenoxicam NSAID	59804-37-4	1g	$288	2024-03-01	Buy
Sigma-Aldrich	BP709	Tenoxicam degradation impurity standard British Pharmacopoeia (BP) Reference Standard	59804-37-4	25MG	$266	2024-03-01	Buy
Sigma-Aldrich	BP708	Tenoxicam British Pharmacopoeia (BP) Reference Standard	59804-37-4	100MG	$223	2024-03-01	Buy
Sigma-Aldrich	T0909	Tenoxicam NSAID	59804-37-4	5g	$1000	2023-06-20	Buy
TCI Chemical	T2750	Tenoxicam	59804-37-4	5G	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
T0909	1g	$288	Buy
BP709	25MG	$266	Buy
BP708	100MG	$223	Buy
T0909	5g	$1000	Buy
T2750	5G	$57	Buy

Tenoxicam Chemical Properties,Uses,Production

Description

Tenoxicam is a non-steroidal antiinflammatory agent with a profile similar to related piroxicam and now withdrawn isoxicam (55). It is useful in the treatment of rheumatoid arthritis, osteoarthritis and related disorders.

Chemical Properties

Yellow Crystalline Powder

Originator

Hoffmann-La Roche (Switzerland)

Uses

Tenoxicam has been used:
    as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
    as a standard in microanalysis of NSAIDs by spectrophotometry
    to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers

Definition

ChEBI: Tenoxicam is a thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a heteroaryl hydroxy compound, a monocarboxylic acid amide, a member of pyridines and a thienothiazine.

brand name

Tilcotil

Biochem/physiol Actions

Tenoxicam (TX) possesses antipyretic?and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.

Clinical Use

NSAID and analgesic

Synthesis

The reaction of methyl 3-hydroxythiophene- 2-carboxylate with PCl5 in refluxing CCl4 gives 3-chlorothiophene-2-carboxylic acid, which by treatment with NaHSO3 and Cu in aqueous alkaline solution at 143 ?C in a pressure vessel is converted into 3- sulfothiophene-2-carboxylic acid. Its esterification with refluxing methanol affords methyl- 3-sulfothiophene-2-carboxylate, which by reaction with refluxing SOCl2 yields methyl- 3-chlorosulfonylthiophene-2-carboxylate. The following condensation with sarcosine ethyl ester in hot CHCl3 gives 3-(N-ethoxycarbonylmethyl- N-methylsulfamoyl)thiophene-2-carboxylate, which is cyclized by treatment with sodium methoxide in refluxing methanol affording 3-ethoxycarbonyl-4-hydroxy-2-methyl-2Hthieno--1,2-thiazine 1,1-dioxide. Finally this compound is condensed with 2-aminopyridine in refluxing toluene

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.

Metabolism

Metabolised in the liver via cytochrome P450 2C9 to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).
Metabolites are excreted mainly in the urine; there is some biliary excretion of glucuronide conjugates of the metabolites.

Tenoxicam synthesis

Synthesis of Tenoxicam from 2-Aminopyridine and METHYL 2-METHYL-4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

Tenoxicam Preparation Products And Raw materials

Raw materials

Ethyl 3-aminopropanoate hydrochloride 3-CHLOROTHIOPHENE Sulfuryl chloride Methyl 3-hydroxythiophene-2-carboxylate 2-Aminopyridine

Sarcosine

1of2

Preparation Products

Tenoxicam Suppliers

Global( 332)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Tosun Pharmaceutical Limited	+8618922120635	sales@toref-standards.com	China	1000	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1066	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3430	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12732	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58

Supplier	Advantage
Guangzhou Tosun Pharmaceutical Limited	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Beijing Yibai Biotechnology Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from Tenoxicam manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-15	Tenoxicam 59804-37-4	US $1.00 / mg	100mg	0.99	5ton/month	ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
2024-04-11	Lornoxicam Impurity 44 59804-37-4	US $0.00-0.00 / mg	1mg	above 96%	50mg	Guangzhou Tosun Pharmaceutical Limited
2024-04-09	Tenoxicam 59804-37-4	US $0.00 / Kg	1Kg	99%	10kg	Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenoxicam
59804-37-4
US $1.00 / mg
0.99
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Lornoxicam Impurity 44
59804-37-4
US $0.00-0.00 / mg
above 96%
Guangzhou Tosun Pharmaceutical Limited

Tenoxicam
59804-37-4
US $0.00 / Kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenoxicam Spectrum

Tenoxicam(59804-37-4)¹HNMR

59804-37-4(Tenoxicam)Related Search:

Chlorantraniliprole Meloxicam Bensulfuron methyl Thiophanate-methyl CHLOROPHOSPHONAZO III

Methyl acrylate Benzamide Piroxicam Lornoxicam N,N-Dimethylformamide

Formamide Kresoxim-methyl 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Methylparaben METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

METHYL 2-METHYL-4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Ampiroxicam Methyl

1of4

4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Tenoxicam) MOBIFLEX tilcotil 3-Chlorosulfonyl-2-thiophene carboxylic acid methy Do1men 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2，3-e]-1，2-thiazine-3-carboxamidel，1-dioxide 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide 4-Hydroxy-2-methyl-N-2-pyrimidinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 4-Hydroxy-2-methyl-3-[(2-pyridyl)carbamoyl]-2H-thieno[2,3-e][1,2]thiazine 1,1-dioxide 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-bisoxide 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Epicotil OxaMen-L Soral TenoxicaM API 4-hydroxy-2-Methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1$l^{6},5,2-thieno[2,3-e][1$l^{6},2]thiazine-3-carboxaMide Tenoxicam Solution, 100ppm 1,1-dioxide-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide TENOXICAM 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE AKOS 93347 3-e)-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-n-2-pyridinyl-2h-thieno( 4-hydroxy-2-methyl-n-2-pyridinyl-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide ro12-0068 TENATOPRAZOLESODIUM 4-Hydroxy-2-(methyl-d3)-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Tenoxicam-(methyl-d3) Tenoxicam (Mobiflex) 4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide TENOXICAM ASSAY STANDARD BP(CRM STANDARD) TENOXICAM BP STANDARD(CRM STANDARD) TENOXICAM EPT(CRM STANDARD) TenoxicamBp98 Alganex Dolmen Liman Rexalgan Tilatil 2H-Thieno(2,3-e)-1,2-thiyzin-3-carboxamid, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxid 69804-37-4 Tenoxicam CRS Tenoxicamum enoxicam Tenoxicam USP/EP/BP Lornoxicam Impurity 44 Mobiflex, Tenoxicam 6-chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3- carboxamide 1,1-dioxide Deschloro analog of lornoxicam/tenoxicam 59804-37-4 156-2-32 69804-37-4 9804-37-4 C13H11N3O4S2 BioChemical Biochemicals and Reagents Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates