Fenbufen
- CAS No.
- 36330-85-5
- Chemical Name:
- Fenbufen
- Synonyms
- bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
- CBNumber:
- CB2239125
- Molecular Formula:
- C16H14O3
- Molecular Weight:
- 254.29
- MDL Number:
- MFCD00056701
- MOL File:
- 36330-85-5.mol
- MSDS File:
- SDS
| Melting point | 184-187 °C (lit.) |
|---|---|
| Boiling point | 357.5°C (rough estimate) |
| Density | 1.1565 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride. |
| pka | pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain) |
| Water Solubility | 2.212mg/L(25 ºC) |
| Merck | 13,3990 |
| FDA UNII | 9815R1WR9B |
| ATC code | M01AE05 |
| EPA Substance Registry System | [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 28-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DV1761000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2918300090 | |||||||||
| Toxicity | LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte) | |||||||||
| NFPA 704 |
|
Fenbufen price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP354 | Fenbufen British Pharmacopoeia (BP) Reference Standard | 36330-85-5 | 100MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | F8755 | Fenbufen analytical standard | 36330-85-5 | 5g | $110 | 2022-05-15 | Buy |
| Alfa Aesar | H60557 | 4-(4-Biphenylyl)-4-oxobutyric acid, 96% | 36330-85-5 | 1g | $45.65 | 2024-03-01 | Buy |
| Alfa Aesar | H60557 | 4-(4-Biphenylyl)-4-oxobutyric acid, 96% | 36330-85-5 | 5g | $151.65 | 2024-03-01 | Buy |
| Cayman Chemical | 28851 | Fenbufen | 36330-85-5 | 5g | $93 | 2024-03-01 | Buy |
Fenbufen Chemical Properties,Uses,Production
Description
Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.
Chemical Properties
White Solid
Originator
Cinopal,Cyanamid,Italy,1976
Uses
muscle relaxant (smooth)
Uses
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory
Definition
ChEBI: Fenbufen is a member of biphenyls and a 4-oxo monocarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug.
Manufacturing Process
135 g of aluminum chloride is dissolved in 500 ml of nitrobenzene, the solution being held below 10°C by external cooling. A finely ground mixture of 50 g of succinic anhydride and 75 g of biphenyl is added to the stirred solution, the temperature being held below 10°C. It is then held at room temperature for four days. After pouring the reaction mixture into a solution of 150 ml of concentrated hydrochloric acid in 1 liter of ice water, the nitrobenzene is removed by steam distillation. The solid is collected, dissolved in 4 liters of 3% hot sodium carbonate solution, clarified, and reprecipitated by the addition of excess 6N sulfuric acid solution. The crude product is collected, dried, and recrystallized from ethanol to give the pure subject compound, MP 185°C to 187°C.
Therapeutic Function
Antiinflammatory
General Description
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Trade name
Clincopal (Lederle, Spain), Lederfen (Lederle, UK), Napanol (Lederle, Japan).
Safety Profile
Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi
Fenbufen Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 288 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from Fenbufen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-22 | Fenbufen
36330-85-5
|
US $100.00-1.00 / kg | 1kg | 99% | 20 tons | Liaoning Pharmaceutical Innovation Co., Ltd | |
 |
2024-01-18 | fenbufen
36330-85-5
|
US $66.00 / KG | 1250KG | 99% | 330T | Xiamen Wonderful Bio Technology Co., Ltd. | |
 |
2023-03-06 | 4-(4-Biphenyl)-4-oxobutyric acid
36330-85-5
|
US $1.90 / KG | 1KG | 99% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD |
-
- Fenbufen
36330-85-5
- US $100.00-1.00 / kg
- 99%
- Liaoning Pharmaceutical Innovation Co., Ltd
-
- fenbufen
36330-85-5
- US $66.00 / KG
- 99%
- Xiamen Wonderful Bio Technology Co., Ltd.
-
- 4-(4-Biphenyl)-4-oxobutyric acid
36330-85-5
- US $1.90 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
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