2(5H)-Furanone
- CAS No.
- 497-23-4
- Chemical Name:
- 2(5H)-Furanone
- Synonyms
- FURANONE;FURAN-2(5H)-ONE;Butenolide;γ-Crotonolactone;2-Furanone;4-Hydroxy-2-butenoic acid gamma-lactone;CARMELAN;2-Butenolide;Crotonolactone;2H-furan-5-one
- CBNumber:
- CB3201475
- Molecular Formula:
- C4H4O2
- Molecular Weight:
- 84.07
- MDL Number:
- MFCD00005376
- MOL File:
- 497-23-4.mol
| Melting point | 4-5 °C (lit.) |
|---|---|
| Boiling point | 86-87 °C/12 mmHg (lit.) |
| Density | 1.185 g/mL at 25 °C (lit.) |
| FEMA | 4138 | 4-HYDROXY-2-BUTENOIC ACID GAMMA-LACTONE |
| refractive index |
n |
| Flash point | 214 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to pale yellow or amber |
| Odor | buttery |
| Odor Type | buttery |
| Water Solubility | Immiscible with water. |
| JECFA Number | 2000 |
| BRN | 383585 |
| Stability | Moisture Sensitive |
| InChIKey | VIHAEDVKXSOUAT-UHFFFAOYSA-N |
| LogP | -0.600 |
| CAS DataBase Reference | 497-23-4(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 4-HYDROXY-2-BUTENOIC ACID GAMMA-LACTONE |
| EWG's Food Scores | 1 |
| FDA UNII | 8KXK25H388 |
| NIST Chemistry Reference | 2(5H)-Furanone(497-23-4) |
| EPA Substance Registry System | 2(5H)-Furanone (497-23-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P280a-P305+P351+P338-P321-P332+P313-P337+P313-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LU3453000 | |||||||||
| F | 8-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29322980 | |||||||||
| NFPA 704 |
|
2(5H)-Furanone price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 283754 | 2(5H)-Furanone 98% | 497-23-4 | 1g | $89.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 283754 | 2(5H)-Furanone 98% | 497-23-4 | 5g | $350 | 2024-03-01 | Buy |
| TCI Chemical | C1078 | gamma-Crotonolactone >93.0%(GC) | 497-23-4 | 5mL | $50 | 2024-03-01 | Buy |
| TCI Chemical | C1078 | gamma-Crotonolactone >93.0%(GC) | 497-23-4 | 25mL | $180 | 2024-03-01 | Buy |
| Alfa Aesar | L13142 | 2(5H)-Furanone, 96% | 497-23-4 | 1g | $62.65 | 2024-03-01 | Buy |
2(5H)-Furanone Chemical Properties,Uses,Production
Chemical Properties
Colorless to pale brown-yellow clear liquid
Chemical Properties
2(5H)-Furanone is light brown liquid
Occurrence
Reported found in coffee
Uses
2(5H)-Furanone is employed in the preparation of 5-substituted 2(5H) furanones (gamma-butenolides) catalyzed by bifunctional aminothiourea and aminosquaramide organocatalysts through direct aldol reaction with aromatic aldehydes. Further, it is used in the synthesis of lignans by Michael addition reactions. In addition to this, it is used in three-component Michael-Aldol reactions with an aldehyde and thiolate or carbanion.
Uses
2(5H)-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.
Uses
2(5H)-Furanone is a versatile reagent used in Michael addition reactions1 for synthesis of lignans.2 Also employed in three-component Michael-Aldol reactions with an aldehyde anda thiolate3 or carbanion.4
Definition
2(5H)-Furanone is a mycotoxin that contains an α,β-unsaturated lactone moiety.
General Description
Chiral urea compounds catalyzed hetero-Michael addition reaction of 2(5H)-furanone (γ-crotonolactone) to pyrrolidine. The quorum sensing inhibition activity by 2(5H)-furanone was studied using bioindicator strains.
Hazard
Extremely toxic.
Purification Methods
Fractionally distil the lactone under reduced pressure. IR: (CCl4) 1784 and 1742 cm-1, UV no max above 205nm ( 1160 cm-1 M-1) and 1HR: (CCl3) : 2.15 (pair of triplets 1H), 3.85 (pair of triplets 1H) and 5.03 (triplet 2H). [Price & Judge Org Synth Coll Vol V 255 1973, Smith & Jones Can J Chem 37 2007, 2092 1959, Beilstein 17/9 V 112.]
2(5H)-Furanone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 8174 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15932 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
View Lastest Price from 2(5H)-Furanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | 2(5H)-Furanone
497-23-4
|
US $5.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-07-19 | 2(5H)-Furanone
497-23-4
|
US $30.00 / KG | 1KG | 99% | 20 Tons | Wuhan wingroup Pharmaceutical Co., Ltd | |
 |
2022-10-26 | 2(5H)-Furanone
497-23-4
|
US $30.00 / kg | 1kg | 99% | 100tons | Hebei Duling International Trade Co. LTD |
-
- 2(5H)-Furanone
497-23-4
- US $5.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2(5H)-Furanone
497-23-4
- US $30.00 / KG
- 99%
- Wuhan wingroup Pharmaceutical Co., Ltd
-
- 2(5H)-Furanone
497-23-4
- US $30.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD