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Sodium hyaluronate

Physicochemical property Sodium Hyaluronate Injection Application in Particular Diseases Pharmacological action Pharmacodynamics Pharmacokinetics Clinical application Usage dosage Adverse reaction Precautions Uses
Sodium hyaluronate
Sodium hyaluronate
CAS No.
9067-32-7
Chemical Name:
Sodium hyaluronate
Synonyms
Sph;Healon;Oegehd;Equron;Opegan;Sl-1010;Si-4402;Hyalein;Nidelon;Synacid
CBNumber:
CB4176691
Molecular Formula:
C14H22NNaO11
Formula Weight:
403.31
MOL File:
9067-32-7.mol

Sodium hyaluronate Properties

alpha 
D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
storage temp. 
−20°C
solubility 
H2O: 5 mg/mL, clear, colorless
form 
Powder
color 
White to cream
Water Solubility 
SOLUBLE
Merck 
13,4776
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
9067-32-7(CAS DataBase Reference)

SAFETY

Hazard Codes  B,Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-27-26
WGK Germany  3
RTECS  MT7250000
3-10

Sodium hyaluronate price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00941 Hyaluronic acid sodium salt from Streptococcus equi mol wt 300,000-500,000 9067-32-7 10mg $370.5 2017-11-08 Buy
Sigma-Aldrich 00941 Hyaluronic acid sodium salt from Streptococcus equi mol wt 300,000-500,000 9067-32-7 50mg $1485 2017-11-08 Buy
Alfa Aesar J66993 Hyaluronic acid sodium salt, Streptococcus equi, 91% 9067-32-7 500mg $42.8 2017-11-08 Buy
Alfa Aesar J66993 Hyaluronic acid sodium salt, Streptococcus equi, 91% 9067-32-7 1g $64.3 2017-11-08 Buy
Sigma-Aldrich 53747 Hyaluronic acid sodium salt from Streptococcus equi bacterial glycosaminoglycan polysaccharide 9067-32-7 1g $70.6 2017-11-08 Buy

Sodium hyaluronate Chemical Properties,Uses,Production

Physicochemical property

Sodium hyaluronate is also called Hyaluronic acid sodium, is physiological active substances, which is widely exists in the human body. It is high molecular weignt straight-chain mucopolysaccharides, which is composed of glucuronic acid and acetyl amino hexose polymerizatio. its molecular weight is 1 million. In water, It can form a thick viscoelastic solution, has the physiological ph and ionic strength. The molecular configuration is variable, so also can be done with a fine needle. Sodium hyaluronate won't produce inflammatory substances , called Healon. The 10 mg dissolved in 1 ml saline solution, its thick viscosity is 200000 times higher than aqueous humor or saline water. Healon protein content is less than 0.5%, and a sterile solution with high purity.
The structure of Sodium hyaluronate
Figure 1 The structure of Sodium hyaluronate

Sodium Hyaluronate Injection

Hyaluronic acid sodium is a class of the non-drug neutral medium. Sodium hyaluronate injection is colorless transparent viscous liquid. Sodium hyaluronate is the main component of synovial joints , one of the components of cartilage matrix,and plays a role of lubrication in articular cavity, can reduce friction between organization, can play a role of the elastic at the same time and act the buffer effect of stress on articular cartilage, has their physiological function. High molecular weight, high concentration and high polymer viscoelasticity of sodium hyaluronate can significantly improve the joint inflammatory reaction, strengthen the function of joint fluid sticky and lubrication, protect the articular cartilage, promote the healing and regeneration of the articular cartilage, relieve pain, and increase the motion of Joint. The common dosage of sodium hyaluronate is: the jaw joints with 1 ml (10 mg), shoulder joint in 2 ml (20 mg), hip and knee with 2.5 ml (25 mg). It is mainly used in the treatment of degenerative osteoarthritis, traumatic arthritis, chronic rheumatic or rheumatoid arthritis, temporal jaw arthritis, femoral head aseptic necrosis.

Application in Particular Diseases

In Osteoarthritis:
  • Four intraarticular hyaluronic acid preparations are available for treating pain associated with OA of the knee: sodium hyaluronate (Hyalgan 20 mg/2 mL; Supartz 25 mg/2.5 mL), hylan polymers (Synvisc 16 mg/2 mL), and hyaluronan (Orthovisc 30 mg/2 mL). Hyalgan and Supartz are administered once weekly for five injections, whereas Synvisc and Orthovisc are administered once weekly for three injections.
  • Injections are well tolerated, but acute joint swelling and local skin reactions (e.g., rash, ecchymoses, or pruritus) have been reported.
  • These products may be beneficial for OA of the knee that is unresponsive to other therapy, but they are expensive because treatment includes both drug and administration costs.

Pharmacological action

Sodium hyaluronate has the effect of promotinig wound healing. Sodium hyaluronate can form a macromolecular network barrier on the surface of eye tissue, preventing inflammatory content into the wound and lesion area, and can obviously increase the viscosity of liquids and adhesion, make the drug reserved and concentrated on the surface of the cornea for a long time, achieving long-term, powerful function. Sodium hyaluronate can stabilize tear film, prolong tear film broken, alleviate symptoms of dry eye. It is used for keratitis, corneal ulcer, the cornea injury caused by physical factors or other chemical burns.

Pharmacodynamics

(1)It can protect corneal endothelial in surgery, epithelium, iris and retina.
(2)It can be instead of aqueous humor without loss, so it can keep the depth of anterior chamber during the surgery.
(3)It is injected into glass cavity ,helping to reset the retina because of oppression.
(4)It can enter the conjunctiva under the pillow to keep filter pillow uplift in glaucoma surgery.
(5) It can help to reduce the adhesion for separation tissue surface.

Pharmacokinetics

Sodium hyaluronate is a component of the aqueous humor and vitreous body. When injected into anterior chamber or vitreous cavity, it can make a temporary increase in the concentration in every parts. In the anterior chamber, Healon gradually dilute by newborn aqueous humor and is discharged through the corner sclera sinus; Injected Healon into the vitreous cavity and again dilute aqueous humor then seep out . The monkey eyes experiment shows that Healon disappear entirely after 60~70 d in vitreous cavity. In the process, the concentration of Healon gradually weakened and its molecular remains the same. Healon injection into Monkey’s anterior chamber disappeared within 1 weeks. Clinical observation is similar to that of human eye.

Clinical application

Used in the surgeries such as intraocular lens, cataracts, glaucoma, corneal transplantation and retinal detachment .

Usage dosage

The injection is used commonly in anterior chamber, and each 0.5~0.5 ml.
In Intraocular lens implant surgery, using Healon can keep up the entire operation process of the depth of anterior chamber, having wide position for the operation of cataract extraction and intraocular lens implantation, also can keep the shape and position of the tissue in anterior chamber to run the operation smoothly and reduce early post-operational complications. Healon which is in corneal transplant applicationcan, can protect the corneal endothelium from the tissue damage.

Adverse reaction

A minority of patients using Healon may be a transient (25~30 MMHG) elevated intraocular pressurewith after operation,then back to normal in 1~2 d. But at the end of the surgery injection balance the brine into anterior chamber to dilute Healon, did not have the phenomenon of elevated intraocular pressure.

Precautions

1.Topical (eye drop) can sometimes have a thrill, foreign body sensation, itching, reddening, diffuse surface keratitis, etc. After eye surgery, this drug with blood or residual crystals mixing in the eye , can delay absorption and inflammation, and short elevated intraocular pressure. Local injection can have a sexual pain swelling or fever. Possible allergies are: sometimes may be blepharitis, eyelid skin inflammation, individual patients can also be a skin rash, itching, rare shock, urticaria, etc.
2. [contraindications]Allergies to this medicine , venous and lymphatic return leg disorders, patients with knee infection or inflammation, Articular cavity infection of acute phase to disable the articular cavity injection. To diabetic patients with no crystal, tis ban to the use of this drug in large quantities in surgery.
3. Caution:Allergies to the drugs, liver dysfunction or a history of liver function obstacle, the elderly, children, pregnancy, nursing mothers.
4. The use of this drug in the operation should be avoiding excessive packing. After the surgery with a balanced salt solution according to the need to remove residual liquid, this can control the intraocular pressure in case of elevated intraocular pressure.
5. When used in osseous arthritis, It can be combined with prednisone dragon. This can relieve pain, and recover joint function.
6. When it used in eye surgery, we should be closely monitoring intraoperative and postoperative intraocular pressure.
About the information about the physical and chemical properties pharmacological action, pharmacokinetics, clinical application usage and dosage of sodium hyaluronate in ophthalmology by chemcialbook editor yaoyao(2015-09-24).

Uses

1.Used in dry eye syndrome.
2.Widely used in high-end cosmetics industry, used in dry eye syndrome.

Chemical Properties

solid

Uses

Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.

Uses

antifungal agent

Uses

prevents thromboembolic complications

Uses

aldosterone antagonist used as an adjunct in the management of chronic heart failure

Uses

suitable as substrate for hyaluronidase

Uses

Surgical aid (ophthalmological).

Sodium hyaluronate Preparation Products And Raw materials

Raw materials

Preparation Products


Sodium hyaluronate Suppliers

Global( 222)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 9974 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1372 55
Henan DaKen Chemical CO.,LTD.
+86-371-55541817
inquiry@dakenchem.com CHINA 2900 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3856 55
Shaanxi Pioneer Biotech Co., Ltd. 18291449694; 029-84385017-8009
029-84385017 sales@pioneerbiotech.com China 2224 56
Dragon Fly INDUSTRY INT'L CO 15065329263
0532-84616141 info@goldenpromiseindustry.com China 20 55
ALB Technology Limited 1-862-139-8728
1-862-139-8728 sales@albtechnology.com United States 2998 55
Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876
027-59721024 richer3322@163.com China 1863 58
BOC Sciences
info@bocsci.com United States 9930 65
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76

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