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Acetylsalicylic acid

What’s acetylsalicylic acid? Chemical property Uses Production method Category Toxicity grading Acute toxicity Flammable hazardous characteristics Handling and storage characteristics Fire extinguishing agent Occupational standard

CAS No.50-78-2
Chemical Name:Acetylsalicylic acid
Synonyms:ASA;ECM;Xaxa;Aspr;Adiro;Aspec;Aspro;Bayer;Novid;ronal
CBNumber:CB5114818
Molecular Formula:C9H8O4
Formula Weight:180.16
MOL File:50-78-2.mol
Acetylsalicylic acid Property
Melting point : 134-136 °C(lit.)
density : 1.35
Fp : 250 °C
storage temp. : Store at RT.
solubility : H2O: 10 mg/mL at 37 °C
form : crystalline
color : white
Water Solubility : 3.3 g/L (20 ºC)
Merck : 14,851
BRN : 779271
Stability:: Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.
CAS DataBase Reference: 50-78-2(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 2-(acetyloxy)-(50-78-2)
EPA Substance Registry System: Benzoic acid, 2-(acetyloxy)-(50-78-2)
Safety
Hazard Codes : Xn
Risk Statements : 22-36/37/38
Safety Statements : 26-36/37/39
RIDADR : UN 1851
WGK Germany : 1
RTECS : VO0700000
TSCA : Yes
PackingGroup : III
Hazardous Substances Data: 50-78-2(Hazardous Substances Data)

Acetylsalicylic acid Chemical Properties,Usage,Production

What’s acetylsalicylic acid?
Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that’s why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete's foot.
Pharmacological actions
Acetylsalicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the formation of obstructive blood clots in surrounding arteries, and inhibit release of platelet response and endogenous ADP, 5-HT, etc., therefore to inhibit second phase other than the first phase of platelet aggregation. The mechanism of action of acetylsalicylic acid is to make platelets cyclooxygenase acetylation, thus inhibiting the formation of ring peroxide, and TXA2 formation is also reduced as well. At the mean time make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. As the cyclooxygenase is inhibited, it impacts blood vessel wall synthesized to be PGI2, the platelet TXA2 synthetic enzymes also to be inhibited; so it would impact formation of both TXA2 and PGI2 when it is large doses. Suitable for ischemic heart disease, after percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, prevent transient ischemic stroke, myocardial infarction and reduce the incidence of arrhythmia.
The above information is edited by the Chemicalbook He Liao Pu.
Chemical property
This product is a white crystalline, with melting point 138~140 ℃, insoluble in water, soluble in alcohol, ether, etc.
Uses
1.Acetylsalicylic acid is the raw material for rodenticide intermediates 4-hydroxycoumarin.
2.Used to make outdoor structural members and equipment parts exposed in highlights, such as the automobile body, agricultural machinery parts, meters and electric lamps, road marking, etc.
3.It is the earliest applied, the most popular and the most common antipyretic analgesics anti-rheumatism medicine, has aspects of pharmacological effects as antipyretic-analgesic and anti-inflammatory, anti-platelet aggregation and works quickly and effectively. Overdosage can be easily diagnosed and treated, with rare allergic reactions. Often used to cold fever, headache, neuralgia, joint ache, muscle pain, rheumatic fever, acute wet sex arthritis, rheumatoid arthritis and toothache, etc. Listed in National Essential Medicine List. Acetylsalicylic acid also works as an intermediate of other medicines.
Production method
Acetylation of salicylic acid: add acetic anhydride (feeding ratio is 0.7889 times of the total salicylic acid) in reaction vessel, and then add two thirds of salicylic acid, stir it and temperature rises. React 40-60min in 81-82℃. Cool it to 81-82 ℃ and keep the temperature for 2h. When free salicylic acid is qualified, cool it to 13 ℃, precipitation crystallization, rejection filter, dry it in 65-70℃ air flow, then we get acetylsalicylic acid.
Category
Toxic substance
Toxicity grading
High toxic
Acute toxicity
Oral-rat LD50: 200 mg/kg; Oral-mice LD50: 250 mg/kg
Flammable hazardous characteristics
Flammable in fire; irritant gas would be decomposed out when heated.
Handling and storage characteristics
Warehouse needs to be ventiIative and dry with low temperature; separate it from oxidant and food additives.
Fire extinguishing agent
Water fog, foam, carbon dioxide, sandy soil.
Occupational standard
TWA 5 mg/m3
Chemical Properties
White Solid
Usage
antifungal
Usage
Axepim Cephalosporin antibiotic
Usage
Analgesic; antipyretic; anti-inflammatory; antithrombotic
Definition
ChEBI: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity.
General Description
Odorless white crystals or crystalline powder with a slightly bitter taste.
Air & Water Reactions
Slowly hydrolyzes in moist air. Has been involved in dust cloud explosions. Water insoluble. Solution in water is acid to methyl red indicator.
Reactivity Profile
The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol.
Fire Hazard
Acetylsalicylic acid is combustible.
Acetylsalicylic acid Preparation Products And Raw materials
Raw materials
Salicylic acid
Preparation Products
Warfarin BENORILATE 3-CARBETHOXY-4-HYDROXYCOUMARIN O-ACETYLSALICYLOYL CHLORIDE
Acetylsalicylic acid Suppliers      Global( 318)Suppliers     
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Shanghai Macklin Biochemical Co.,Ltd. 15221275939021-51821727shenlinxing@macklin.cnChina 13254 55
Wuhan HongxinKang Fine Chemical Co., Ltd. 027-59362599 18674037007027-84802889zhuoxingwc@163.comChina 942 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333021-50323701sale@aladdin-e.comChina 28587 65
Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876027-59721024richer3322@163.comChina 1859 58
Zhuhai JiaYi Biological Technology Co., Ltd. 18928018694 0756-88110270756-8811027steroidbest@hotmail.comChina 198 58
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 180187192070755-85201366sales@regentbiochem.comChina 299 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)+86-21-57758967sales@boylechem.comChina 2221 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.comChina 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comChina 40403 62
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