Cefotiam

Cefotiam Properties

Boiling point	843℃
Density	1.80±0.1 g/cm3(Predicted)
RTECS	XI0366000
Flash point	>110°(230°F)
storage temp.	2-8°C
pka	2.57±0.50(Predicted)
Water Solubility	Soluble
CAS DataBase Reference	61622-34-2(CAS DataBase Reference)
FDA UNII	91W6Z2N718
ATC code	J01DC07

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Cefotiam price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0001900	CEFOTIAM 95.00%	61622-34-2	100MG	$1127.86	2021-12-16	Buy
American Custom Chemicals Corporation	API0001900	CEFOTIAM 95.00%	61622-34-2	1G	$2355.15	2021-12-16	Buy
Crysdot	CD31001274	Cefotiam 95+%	61622-34-2	1g	$1186	2021-12-16	Buy
AvaChem	2021B	Cefotiam	61622-34-2	25mg	$39	2021-12-16	Buy
AvaChem	2021B	Cefotiam	61622-34-2	100mg	$89	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0001900	100MG	$1127.86	Buy
API0001900	1G	$2355.15	Buy
CD31001274	1g	$1186	Buy
2021B	25mg	$39	Buy
2021B	100mg	$89	Buy

Cefotiam Chemical Properties,Uses,Production

Originator

Cefotiam,Qingdao Ftz United International Inc.

Uses

Antibacterial

Definition

ChEBI: A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalospo in antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.

Manufacturing Process

2 mmol of 7-acetamindocephalosporinic acid in phosphate buffer (pH 7), 2 mmol of 1-(2-dimethylaminoethyl-1H-tetrazol-5-thiol and 2.2 mmol of sodium hydrogen carbonate are mixed and resulting solution was stirred at 60°-65°C for 16 hours. After cooling the mixture was adjusted pH 3.6 and hydrochloride of NH2OH was added to give 7-amino-3-[2-(2-dimethylaminoethyl)-2H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2- carboxylic acid.
0.4 g (2 mmol) of 2-(2-aminothiazol-4-yl)acetic acid hydrochloride in 10 ml of dimethylformamide are dissolved, 0.25 g (2.2 mmol) of N-hydroxysuccinimide and 0.412 g (2 mmol) of dicyclohexylcarbodiimide and the solution is allowed to stand at room temperature for 3 hours. The reaction mixture is subjected to filtration under suction to remove the precipitate of N,N'-dicyclohexylurea. The filtrate is added at a stroke to a solution of 2 mmol of above prepared 7- amino-3-[2-(2-dimethylaminoethyl)-2H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5- thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 0.404 g (4 mmol) of triethylamine in 20 ml of dichloromethane and the mixed solution is stirred for 24 hours at room temperature. The solvent is distilled off under reduced pressure and the residue is adjusted pH from to 6 to 7 by adding a 10% aqueous solution of sodium hydrogen carbonate. The resultant solution is chromatographed on column of polystyrene resin (Amberlite XAD-2) and developed with water. The fractions containing the desired product are pooled and freeze-dried to obtain the title product.

brand name

Ceradon (Takeda).

Therapeutic Function

Antibiotic

Antimicrobial activity

A semisynthetic cephalosporin formulated as the dihydrochloride for injection and as a prodrug ester, cefotiam hexetil, for oral administration. Activity is similar to that of cefuroxime, but it is somewhat more active against a range of enterobacteria .
A 30-min intravenous infusion of the dihydrochloride produces a peak serum concentration of 35 mg/L; the corresponding concentration after a 1 g intramuscular dose is 17 mg/L. Oral absorption of the hexetil ester is around 65%. Food delays absorption of the ester. The plasma half-life is 0.6–1.1 h. Around 40% is bound to plasma protein. Urinary excretion is almost complete 4 h after the end of intravenous infusion, but only 50–67% is recovered unchanged; there is substantial non-renal elimination and some evidence of saturation of renal tubular excretion at doses above 2 g. In anuria the plasma elimination half-life rises to 13 h and plasma and renal clearances parallel creatinine clearance. A small amount is excreted in bile. In patients with cholelithiasis given 0.5 or 1 g intravenously, mean concentrations in gallbladder bile and gallbladder wall 30 min after the dose were around 17 and 32 mg/L, respectively. In patients with normal liver function, hepatic bile concentrations can exceed 1 g/L.
It is generally well tolerated and has been used successfully to treat lower respiratory infections, skin and soft-tissue infection. It is not widely used, but is available in Japan and some other countries.

Cefotiam Preparation Products And Raw materials

Raw materials

Cefotiam Hydrochloride 2-N-BUTOXYETHYL METHACRYLATE MERCAPTANS 1H-TETRAZOLE Sodium azide

(+)-MENTHYL CHLOROFORMATE Carbon dioxide Ethyl isothiocyanate Magnesium sulfate 2-Aminothiazole-4-acetic acid

Hydroxylamine hydrochloride Triethylamine AMBERLITE 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol N-Hydroxysuccinimide

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Preparation Products

Cefotiam Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15745	58

Supplier	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hebei Duling International Trade Co. LTD	58

View Lastest Price from Cefotiam manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-12	Cefotiam 61622-34-2	US $0.00 / kg	1kg	99%	10000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-04-10	Cefotiam 61622-34-2	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC
2021-07-01	Cefotiam USP/EP/BP 61622-34-2	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Cefotiam
61622-34-2
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Cefotiam
61622-34-2
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

Cefotiam USP/EP/BP
61622-34-2
US $1.10 / g
99.9%
Dideu Industries Group Limited

61622-34-2(Cefotiam)Related Search:

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ALTRENOGEST Acetyl coenzyme A sodium salt Tris(hydroxymethyl)aminomethane CEFOTIAM 2HCL,cefotiam hydrochloride 2-Dimethylaminoethanol

CefotiaM Hexetil Hydrochloride 2-(2-aminothiazole-4-yl)acetic acid hydrochloride (intermediate of cefotiam) cefotiam hexetil hydrochloride

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8-[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino-4-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid (6r-trans)--oxo )acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8 cgp14221e CEFOTIAM CEFOTIAM HCL 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R-trans)- SCE 963 Cefotiam (base and/or unspecified salts) (6R-trans)-7-[[(2-Amino-4-thiazlyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-y1]thio]methyl]-8-oxo-5-thia-1-azabi-cyclo[4.2.0]oct-2-ene-2-carboxylic acid Pansporin T Pansporin：Pansporine Taketiam Texodil (6R,7R)-7α-[(2-Amino-4-thiazolyl)acetylamino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-, (6R,7R)- Cefotiam Crude N-acetylneuraminic Cefotiam USP/EP/BP 61622-34-2