3,3',5-TRIIODOTHYROACETIC ACID
- CAS No.
- 51-24-1
- Chemical Name:
- 3,3',5-TRIIODOTHYROACETIC ACID
- Synonyms
- TIRATRICOL;TRIAC;Levothyroxine EP Impurity C;T3A;Nidolin;Triacana;Tilaquke;TRIIODOTHYROACETICACID;Levothyroxine Impurity C;Liothyronine EP Impurity C
- CBNumber:
- CB8275848
- Molecular Formula:
- C14H9I3O4
- Molecular Weight:
- 621.93
- MDL Number:
- MFCD00055931
- MOL File:
- 51-24-1.mol
- MSDS File:
- SDS
| Melting point | 65°; mp 180-183° |
|---|---|
| Boiling point | 531.6±50.0 °C(Predicted) |
| Density | 2.466±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) |
| form | Solid |
| pka | 4.02±0.10(Predicted) |
| color | White to Pale Beige |
| FDA UNII | 29OQ9EU4R1 |
| ATC code | D11AX08,H03AA04 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916.39.7900 | |||||||||
| NFPA 704 |
|
3,3',5-TRIIODOTHYROACETIC ACID price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T7650 | 3,3′,5-Triiodothyroacetic acid ≥90% | 51-24-1 | 100mg | $135 | 2024-03-01 | Buy |
| Sigma-Aldrich | T7650 | 3,3′,5-Triiodothyroacetic acid ≥90% | 51-24-1 | 1g | $620 | 2024-03-01 | Buy |
| TCI Chemical | T3878 | 3,3',5-Triiodothyroacetic Acid | 51-24-1 | 200MG | $176 | 2024-03-01 | Buy |
| TCI Chemical | T3878 | 3,3',5-Triiodothyroacetic Acid | 51-24-1 | 1G | $337 | 2021-12-16 | Buy |
| Cayman Chemical | 28729 | Tiratricol | 51-24-1 | 100mg | $61 | 2024-03-01 | Buy |
3,3',5-TRIIODOTHYROACETIC ACID Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Originator
Triacana,Ana,Italy,1972
Uses
3,3'',5-Triiodo Thyroacetic Acid (T3-Acetic Acid (USP)) is a thyroid hormone analogue. A potent Thyroxine impurity. Levothyroxine EP Impurity C.
Uses
thyroid agent
Manufacturing Process
Preparation of 3:5-diiodo-4-(4'-hydroxyphenoxy)phenylacetic acid (diacid): A
solution of ethyl 3:5-diiodo-4-(4'-methoxyphenoxy)phenyl acetate (9.5 g) in
acetic acid (60 ml) was heated under reflux with hydroiodic acid (SG 1.7, 50
ml) and red phosphorus (0.5 g) for 1 hour. The hot solution was filtered and
the filtrate concentrated at 50°C and 15 mm of mercury to above 20 ml. The
residue was treated with water (70 ml) containing a little sodium thiosulfate
to decolorize the product. The solid was collected by filtration and purified by
the method of Harington and Pitt-Rivers [Biochem. J. (1952), Vol. 50, page
438]. Yield 8.36 g (95%). After crystallization from 70% (v/v) acetic acid it
melted at 219°C.
A solution of 438 mg of diac in methanol (20 ml) and ammonia solution (SG
0.88; 20 ml) was iodinated at 0°C with 1.8 ml 1 N iodine solution. The
product was isolated in almost theoretical yield in a manner similar to that
described for tetrac. After crystallization from 50% (v/v) methanol, triac was
obtained as colorless needles which melted over the range 65°C to 90°C
according to the rate of heating. The molten form resolidified at about 110°C
and finally melted at 180°C to 181°C without decomposition. The compound,
dried at 25°C/3 mm over silica gel, contains methanol of crystallization.
Therapeutic Function
Thyroid hormone
3,3',5-TRIIODOTHYROACETIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 | wangwendy93@gmail.com | China | 868 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from 3,3',5-TRIIODOTHYROACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Tiratricol
51-24-1
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2021-09-29 | Tiratricol
51-24-1
|
US $0.00 / g | 1g | 95%101% HPLC | 1000G | WUHAN FORTUNA CHEMICAL CO., LTD | |
![2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid pictures](https://img.chemicalbook.com/ProductImageEN/2020-2/Small/93e2a13a-92cc-4d51-b5df-48d052524db3.jpg) |
2020-02-17 | 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
51-24-1
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- Tiratricol
51-24-1
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- Tiratricol
51-24-1
- US $0.00 / g
- 95%101% HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
51-24-1
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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