Loxapine succinate salt
- CAS No.
- 27833-64-3
- Chemical Name:
- Loxapine succinate salt
- Synonyms
- S-805;loxapac;lederle;cl71563;SUM-317;Daxolin;loxitane;daxoline;CL-62362;SUM-3170
- CBNumber:
- CB8709350
- Molecular Formula:
- C22H24ClN3O5
- Molecular Weight:
- 445.9
- MDL Number:
- MFCD00069298
- MOL File:
- 27833-64-3.mol
| Melting point | 150-152°C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| CAS DataBase Reference | 27833-64-3(CAS DataBase Reference) |
| FDA UNII | X59SG0MRYU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| RIDADR | UN 2811 6.1 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WM5750000 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Loxapine succinate salt price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L106 | Loxapine succinate salt solid | 27833-64-3 | 100mg | $67.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1370702 | Loxapine succinate United States Pharmacopeia (USP) Reference Standard | 27833-64-3 | 125mg | $358 | 2024-03-01 | Buy |
| Cayman Chemical | 20760 | Loxapine (succinate) ≥98% | 27833-64-3 | 50mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20760 | Loxapine (succinate) ≥98% | 27833-64-3 | 100mg | $54 | 2024-03-01 | Buy |
| Sigma-Aldrich | L106 | Loxapine succinate salt solid | 27833-64-3 | 500mg | $273 | 2023-06-20 | Buy |
Loxapine succinate salt Chemical Properties,Uses,Production
Description
Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.
Description
Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.
Chemical Properties
White to Of-White Solid
Uses
Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.
Uses
choleretic
Uses
A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent
brand name
Loxapine (Mylan); Loxitane (Watson).
Toxicity evaluation
Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.
Loxapine succinate salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from Loxapine succinate salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Loxapine succinate salt
27833-64-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Loxapine succinate salt
27833-64-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Loxapine succinate salt
27833-64-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Loxapine succinate salt
27833-64-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd