Lorcainide
- CAS No.
- 59729-31-6
- Chemical Name:
- Lorcainide
- Synonyms
- R-15889;Lorcamide;Lopantrol;Lorcainide;Ro-13。1042;Lorivox：Remivox;Lorcainide USP/EP/BP;N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
- CBNumber:
- CB8875468
- Molecular Formula:
- C22H27ClN2O
- Molecular Weight:
- 370.92
- MDL Number:
- MFCD00242744
- MOL File:
- 59729-31-6.mol
| Melting point | 263 °C |
|---|---|
| Boiling point | 503.0±50.0 °C(Predicted) |
| Density | 1.161±0.06 g/cm3(Predicted) |
| pka | 9.48±0.20(Predicted) |
| FDA UNII | KGJ2T0N7IQ |
| ATC code | C01BC07 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom) |
|---|
Lorcainide Chemical Properties,Uses,Production
Originator
Remivox,Janssen,W. Germany,1980
Uses
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: Lorcainide is a member of acetamides.
Manufacturing Process
To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane is added and stirring and refluxing is continued for another 19 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2 parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl] benzeneacetamide hydrochloride; melting point 263°C.
Therapeutic Function
Antiarrhythmic
Side effects
Side effects include insomnia and gastrointestinal disturbances.
Lorcainide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| DebyeTec.com Inc. | 18086626237 18086626237 | sales@debyesci.com | China | 2643 | 56 |
View Lastest Price from Lorcainide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Lorcainide USP/EP/BP
59729-31-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-20 | Lorcainide
59729-31-6
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Lorcainide USP/EP/BP
59729-31-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Lorcainide
59729-31-6
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd