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Licofelone

Licofelone structure

CAS No.: 156897-06-2

Chemical Name:: Licofelone

Synonyms: icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid

CBNumber:: CB91385206

Molecular Formula:: C23H22ClNO2

Molecular Weight:: 379.88

MDL Number:: MFCD00929900

MOL File:: 156897-06-2.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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Licofelone Properties

Melting point	162-163°C
Boiling point	539.7±50.0 °C(Predicted)
Density	1.23
storage temp.	-20°C Freezer
solubility	Chloroform, Methanol
pka	4.47±0.10(Predicted)
form	Solid
color	Off-White to Light Yellow
CAS DataBase Reference	156897-06-2(CAS DataBase Reference)
FDA UNII	P5T6BYS22Y

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319
Precautionary statements	P305+P351+P338

Licofelone price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10007692	Licofelone ≥98%	156897-06-2	1mg	$55	2024-03-01	Buy
Cayman Chemical	10007692	Licofelone ≥98%	156897-06-2	5mg	$158	2024-03-01	Buy
Cayman Chemical	10007692	Licofelone ≥98%	156897-06-2	10mg	$289	2024-03-01	Buy
Cayman Chemical	10007692	Licofelone ≥98%	156897-06-2	50mg	$1305	2024-03-01	Buy
TRC	L397730	Licofelone	156897-06-2	1mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
10007692	1mg	$55	Buy
10007692	5mg	$158	Buy
10007692	10mg	$289	Buy
10007692	50mg	$1305	Buy
L397730	1mg	$50	Buy

Licofelone Chemical Properties,Uses,Production

Description

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E₂, leukotriene B₄, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC₅₀ values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Chemical Properties

Yellowish Solid

Uses

Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.

in vitro

the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1]

in vivo

the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1]

IC 50

inhibitor of cox-1, cox-2 and 5-lox with ic50 values of 0.16 m, 0.37 m and 0.23 m respectively in human.

References

[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63.

Licofelone Preparation Products And Raw materials

Raw materials

Preparation Products

Licofelone Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Licofelone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	Licofelone 156897-06-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-01-19	Licofelone 156897-06-2	US $3.00 / KG	1KG	99%	1kg,5kg,50kg	Career Henan Chemical Co

Licofelone
156897-06-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Licofelone
156897-06-2
US $3.00 / KG
99%
Career Henan Chemical Co

Licofelone Spectrum

Licofelone(156897-06-2)¹HNMR

156897-06-2(Licofelone)Related Search:

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METHYL-2-PYRROLIDONE 1-METHYL-PYRROLE-2-ACETIC ACID 2,5-DIMETHYL-1-PROPYL-1H-PYRROLE

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2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid Licofelone, ML-3000 [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid ML 3000 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid Licofelone 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl- Licofelone, >=99% icofeL Licofelone USP/EP/BP 16-dihydrotanshinone I 156897-06-2 C23H22ClNO2 Intermediates & Fine Chemicals Pharmaceuticals Inhibitors