Nilvadipine | 75530-68-6

Nilvadipine Properties

Melting point	148-150°C
Boiling point	511.83°C (rough estimate)
Density	1.3937 (rough estimate)
refractive index	1.5900 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble15mg/mL, clear
form	powder
pka	-0.81±0.70(Predicted)
color	white to beige
Merck	14,6545
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII	0214FUT37J
ATC code	C08CA10

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319

Precautionary statements

P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312

Hazard Codes

Xn

Risk Statements

22

WGK Germany

3

RTECS

US7968300

HS Code

2933.39.9200

Toxicity

LD50 oral in rat: 1560mg/kg

NFPA 704

	0
3		0

Nilvadipine price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0945	Nilvadipine ≥98% (HPLC)	75530-68-6	10mg	$58.2	2024-03-01	Buy
Sigma-Aldrich	SML0945	Nilvadipine ≥98% (HPLC)	75530-68-6	50mg	$163	2024-03-01	Buy
TCI Chemical	N0899	Nilvadipine >95.0%(N)	75530-68-6	1g	$108	2024-03-01	Buy
TCI Chemical	N0899	Nilvadipine >95.0%(N)	75530-68-6	5g	$322	2024-03-01	Buy
Cayman Chemical	21243	Nilvadipine ≥98%	75530-68-6	5mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0945	10mg	$58.2	Buy
SML0945	50mg	$163	Buy
N0899	1g	$108	Buy
N0899	5g	$322	Buy
21243	5mg	$32	Buy

Nilvadipine Chemical Properties,Uses,Production

Description

Nilvadipine is a new, second-generation calcium channel blocker effective in the treatment of hypertension and angina pectoris. Its potent inhibitory effect on the stimulated chemotaxis of smooth muscle cells and protective action against calcium deposition suggest that nilvadipine may be useful for preventing and treating atherosclerosis.

Chemical Properties

Yellow Prisms

Originator

Fujisawa (Japan)

Uses

Used as an antihypertensive and antianginal.

Uses

antihypertensive;calcium channel blocker

Definition

ChEBI: Nilvadipine is an isopropyl ester, a methyl ester, a nitrile and a dihydropyridine.

Manufacturing Process

To a solution of isopropyl ester of 6-formyl-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine- 3-carboxylic acid (4.5 g) in acetic acid (35 ml) were added hydroxylamine hydrochloride (0.97 g) and sodium acetate (1.43 g), and the mixture was stirred at ambient temperature for 2.5 hours. After acetic anhydride (4.14 g) was added to this reaction mixture, the mixture was stirred at ambient temperature for 1.5 hours and at 95-100°C for additional 4 hours. The acetic acid and the excess of acetic anhydride were removed in vacuum, followed by adding water to the residue and it was neutralized with a saturated aqueous solution of sodium bicarbonate. This aqueous suspension was extracted twice with ethyl acetate, and the combined extract was washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure to give a reddish-brown oil (4.88 g), which was chromatographed over silica gel (150 g) with a mixture of benzene and ethyl acetate (10:1 by volume) as an eluent to give a crude crystals (2.99 g). These were recrystallized from ethanol to give yellow prisms (1.89 g) of isopropyl ester of 6-cyano-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid melting point 148-150°C (yellow prisms from ethanol); [α]D20 = 222.4° (c = 1 in methanol).

brand name

Nivadil

Therapeutic Function

Calcium entry blocker, Antihypertensive

References

1) Paris?et al. (2014),?The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation; J. Biol. Chem.,?289?33927 2) Rosenthal (1994),?Nilvadipine: profile of a new calcium antagonist. An overview; J. Cardiovasc. Pharmacol. 24 Suppl 2?S92 3) Nimmrich and Eckert (2013),?Calcium channel blockers and dementia; Br. J. Pharmacol.?169?1203 4) Otori?et al. (2003),?Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells; Brain Res.?961?213

Nilvadipine Preparation Products And Raw materials

Raw materials

Erythromycin Estolate Methyl 4,4-dimethoxyacetylacetate (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Hydroxylamine hydrochloride

Crotonic acid HYDROXYLAMINE Acetic anhydride Topotecan Sodium acetate

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Preparation Products

Nilvadipine Suppliers

Global( 172)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9271	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	816	58

Supplier	Advantage
career henan chemical co	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Xi'an ZB Biotech Co.,Ltd	58

View Lastest Price from Nilvadipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-07	Nilvadipine USP/EP/BP 75530-68-6	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2020-05-12	Nilvadipine 75530-68-6	US $0.00-0.00 / KG	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	Nilvadipine 75530-68-6	US $7.00 / KG	1KG	99%	1000KG	Career Henan Chemical Co

Nilvadipine USP/EP/BP
75530-68-6
US $1.10 / g
99.9%
Dideu Industries Group Limited

Nilvadipine
75530-68-6
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

Nilvadipine
75530-68-6
US $7.00 / KG
99%
Career Henan Chemical Co

Nilvadipine Spectrum

Nilvadipine(75530-68-6)MS Nilvadipine(75530-68-6)¹HNMR Nilvadipine(75530-68-6)¹³CNMR Nilvadipine(75530-68-6)IR1 Nilvadipine(75530-68-6)IR2

75530-68-6(Nilvadipine)Related Search:

ISOPROPYL LAURATE Methylparaben Tribenuron methyl Isopropyl acetate Isopropyl alcohol

Dihydromyrcenol Propyl acetate Methanol Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Propyl gallate

Nisoldipine Nitrendipine Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester M-NIFEDIPINE

Nilvadipine (R)-(+)-Nilvadipine,(R)-Nilvadipine (S)-(-)-Nilvadipine,(S)-Nilvadipine

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2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-5-pyridinedicarboxylicacid 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-methyl ester BAY-e-6927 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-isopropyl ester O3-methyl ester 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate O3-methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Nilvadipine (ARC029) Nivadip 3,5-Pyridinedicarboxylicacid, 2-cyano-1,4-dihydro-6-Methyl-4-(3-nitrophenyl)-, 3-Methyl5-(1-Methylethyl) ester 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate ARC029 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate Isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate SKF- Nilvadipine-d4 Nilvadipine, >=99% 3-methyl-5-(1-methylethyl)ester fk235 SKF-102362 NILVADIPINE 2-CYANO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 3-METHYL 5-(1-METHYLETHYL) ESTER 5-isopropyl-3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Isopropyl-6-formyl-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3-carboxylate FR-34235 Nilvaldipine 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester, FR-34235, SKF-102362, Escor, 3,5-Pyridinedicarboxylic acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester (9CI) CL 287389 dl-Nilvadipine Nivadil Escor：Nivadil Nivadipine Nivaldipine Nilvadipine Impurity FK235;ESCOR;FR34235;NIVADIL;NIVADIP 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester Nilvadipine> Nilvadipine RS 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester Nilvadipine USP/EP/BP ESCOR Nilvadipine, ≥ 95.0% 75530-68-6 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals