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Isopropyl acetate

CAS No.
108-21-4
Chemical Name:
Isopropyl acetate
Synonyms
IPAC;IPrOAc;propan-2-yl acetate;CH3COOCH(CH3)2;Ispropyl acetate;Isopropylacetat;2-propylacetate;2-acetoxypropane;2-Propyl acetate;ACETIC ACID ISOPROPYL ESTER
CBNumber:
CB6852740
Molecular Formula:
C5H10O2
Molecular Weight:
102.13
MDL Number:
MFCD00008877
MOL File:
108-21-4.mol
MSDS File:
SDS
Last updated:2023-09-07 18:57:57

Isopropyl acetate Properties

Melting point -73 °C
Boiling point 88.8 °C
Density 0.872 g/mL at 25 °C(lit.)
vapor density 3.5 (vs air)
vapor pressure 47 mm Hg ( 20 °C)
FEMA 2926 | ISOPROPYL ACETATE
refractive index n20/D 1.377(lit.)
Flash point 62 °F
storage temp. Store below +30°C.
solubility 1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless
form Liquid
color Clear colorless
Odor Pleasant, fruity; nonresidual.
Odor Threshold 0.16ppm
explosive limit 1.8%, 37°F
Odor Type ethereal
Evaporation Rate 3
Water Solubility 2.90 g/100 mL
FreezingPoint -73.4℃
Sensitive Moisture Sensitive
JECFA Number 305
Merck 14,5205
BRN 1740761
Exposure limits TLV-TWA 250 ppm (~950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (~1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH).
Stability Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber.
LogP 1.03-1.18 at 20℃
Substances Added to Food (formerly EAFUS) ISOPROPYL ACETATE
FDA 21 CFR 172.515; 175.105; 177.1200
CAS DataBase Reference 108-21-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 1Y67AFK870
NIST Chemistry Reference Acetic acid, 1-methylethyl ester(108-21-4)
EPA Substance Registry System Isopropyl acetate (108-21-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P233-P261-P280-P303+P361+P353-P370+P378
Hazard Codes  F,Xi
Risk Statements  11-36/37/38-67-66-36
Safety Statements  16-26-36-33-29
RIDADR  UN 1220 3/PG 2
WGK Germany  1
RTECS  AI4930000
Autoignition Temperature 894 °F
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29153900
Toxicity LD50 orally in rats: 6.75 g/kg (Smyth)
IDLA 1,800 ppm
NFPA 704
3
2 0

Isopropyl acetate price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W292605 Isopropyl acetate ≥99%, FCC 108-21-4 1kg $76.5 2024-03-01 Buy
Sigma-Aldrich W292605 Isopropyl acetate ≥99%, FCC 108-21-4 9kg $311 2024-03-01 Buy
Sigma-Aldrich W292605 Isopropyl acetate ≥99%, FCC 108-21-4 20kg $565 2024-03-01 Buy
Sigma-Aldrich PHR2109 Isopropyl acetate Pharmaceutical Secondary Standard; Certified Reference Material 108-21-4 3X1.2ML $185 2024-03-01 Buy
Sigma-Aldrich 90871 Isopropyl acetate analytical standard 108-21-4 5ML $102 2024-03-01 Buy
Product number Packaging Price Buy
W292605 1kg $76.5 Buy
W292605 9kg $311 Buy
W292605 20kg $565 Buy
PHR2109 3X1.2ML $185 Buy
90871 5ML $102 Buy

Isopropyl acetate Chemical Properties,Uses,Production

Chemical Properties

Isopropyl acetate is a colourless liquid with an intense, fruity odor. On dilution, it has a sweet apple-like flavor. Miscible with most organic solvents such as alcohols, ketones and ethers. 2.9% (w/w) soluble in water at 20°C. Synthesized by direct acetylation of isopropyl alcohol in the presence of various catalysts: concentrated H2S04, diethyl sulfate, chlorosulfonic acid, and boron trifluoride.

Physical properties

Clear, colorless liquid with an aromatic odor. Experimentally determined detection and recognition odor threshold concentrations were 2.1 mg/m3 (500 ppbv) and 3.8 mg/m3 (910 ppbv), respectively (Hellman and Small, 1974).

Occurrence

Reported found in pineapple, pear, cocoa, apple, banana, black currants, grapes, melons, strawberry, cheddar cheese, beer, white wine, red wine, cocoa, honey, soybean, yellow passion fruit, beans, plum brandy and nectarines

Uses

Isopropyl acetate is used as a solvent for nitrocellulose, plastics, oils, and fats, and as a flavoring agent. Isopropyl Acetate is a widely used chemical solvent in organic and industrial syntheses. Also used in the dissolution of gallstones. Environmental contaminants; Food contaminants.

Application

Isopropyl acetate is a solvent in chemical industry, especially for cellulose, plastics, waxes, resins, gums, paints, oil and fats. and also as flavoring agent. It is an active component of perfumes and printing inks. It is also employed as an extractant for the preparation of antibiotics, vitamins and hormones.

Definition

ChEBI: Isopropyl acetate is a branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.

Preparation

Isopropyl acetate is prepared from propylene and anhydrous acetic acid in the presence of a catalyst . It may also be produced by direct acetylation of isopropyl alcohol in the presence of various catalysts; concentrated H2SO4, diethyl sulfate, chlorosulfonic acid and boron trifluoride.

Aroma threshold values

Detection; 1.7 to 4.4 ppm

Taste threshold values

Taste characteristics at 60 ppm: ethereal, tutti-frutti, with a fruity apple and banana nuance

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3728, 1974 DOI: 10.1021/jo00939a026

General Description

Isopropyl acetate appears as a clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.

Air & Water Reactions

Highly flammable. Less dense than water and slightly soluble in water.

Reactivity Profile

Isopropyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Isopropyl acetate can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. Isopropyl acetate may also attack some forms of rubber, plastics and coatings. .

Health Hazard

Isopropyl acetate is an irritant to the eyes,nose, and throat. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed. The acute toxicity in laboratory animals was low. Exposure to highconcentrations in air or ingestion can produce narcotic effects. A 4-hour exposure to aconcentration of 32,000 ppm in air was fatalto rats (ACGIH 1986). The oral LD50 valuein rats is in the range 6000 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Source

Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

Environmental Fate

Chemical/Physical. Hydrolyzes in water forming isopropyl alcohol and acetic acid (Morrison and Boyd, 1971). The estimated hydrolysis half-life at 25 °C and pH 7 is 8.4 yr (Mabey and Mill, 1978).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 319 mg/L. The adsorbability of the carbon used was 137 mg/g carbon (Guisti et al., 1974).

Purification Methods

Wash the acetate with 50% aqueous K2CO3 (to remove acid), then with saturated aqueous CaCl2 (to remove any alcohol). Dry it with CaCl2 and fractionally distil it. [Beilstein 2 IV 141.]

Isopropyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

1of8

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View Lastest Price from Isopropyl acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isopropyl acetate pictures 2023-11-08 Isopropyl acetate
108-21-4
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Isopropyl acetate pictures 2023-08-12 Isopropyl acetate
108-21-4
US $10.00 / kg 1kg 99.99% 50000tons Henan Bao Enluo International TradeCo.,LTD
Isopropyl acetate pictures 2023-07-27 Isopropyl acetate
108-21-4
US $1.50 / g 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
  • Isopropyl acetate pictures
  • Isopropyl acetate
    108-21-4
  • US $10.00 / kg
  • 99.99%
  • Henan Bao Enluo International TradeCo.,LTD
ISOPROPYL ACETATE FEMA 2926 ISO-PROPYLE ACETATE iso-propyl acetaate ISOPROPYL ACETATE, STANDARD FOR GC ISOPROPYL ACETATE 99+% FCC ISOPROPYL ACETATE, 99.6+% ISOPROPYL ACETATE GC STANDARD PROPYL ISO, ACETATE 1-METHYL ETHYL ACETATE 2-Methylethylethanoate Isopropyl acetate, 99+%, for analysis Ispropyl acetat Isopropyl acetate, 99.5% Isopropyl acetate puriss. p.a., >=99.5% (GC) Isopropyl acetate, 99%, pure Isopropyl Acetate (1.2 mL/ampule Isopropyl acetate, pure, 99% 1LT Isopropyl acetate, pure, 99% 2.5LT 1-Methylethylethanoate isopropile(acetatodi) Isopropyl ester of acetic acid Isopropyl ethanoate Isopropyl(acetate d') isopropyl(acetated’) Isopropylacetaat isopropyle(acetated’)(french) Isopropylester kyseliny octove isopropylesterkyselinyoctove Isopropylethanoate paracetat Isopropyl acetate, pure, 99+% ISOPROPYLACETATEESTER Essigsureisopropylester Isopropyl acetate, 99+% 2-propylethanoate Acetate d'isopropyle acetated’isopropyle acetated’isopropyle(french) Acetic acid, 2-propyl ester Ethanoicacid,isopropylester Isopropile(acetato di) propylacetate(non-specificname) sec-Propyl acetate so-Propyl acetate Isopropyl acetate, for analysis Isopropyl acetate, pure, 99% Isopropyl acetate(IPAC) Isopropyl Acetate > IsopropylAcetateSolution,1000mg/L,1ml IsopropylAcetateSolution,2000mg/L,1ml IsopropylAcetateSolution,200mg/L,1ml ISOPROPYL ACETATE FOR SYNTHESIS ISOPROPYL ACETATE FO Isopropyl acetate USP/EP/BP ISO PROPYL ACETATE Extra Pure ACETIC ACID, 1-METHYLETHYL ESTER IPrOAc