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Dextran Sulfate Sodium Salt

Description Uses Toxicity
Dextran Sulfate Sodium Salt
Dextran Sulfate Sodium Salt
CAS No.
9011-18-1
Chemical Name:
Dextran Sulfate Sodium Salt
Synonyms
asuro;dexnon;ds-m-1;dexulate;Ccris 196;dextrarine;DEXSATEMPO(TM);DEXTRALIP(R) 50;DEXTRAN SULFATE;DEXTRAN SULPHATE
CBNumber:
CB9339022
Molecular Formula:
(C6H7Na3O14S3)n
Formula Weight:
0
MOL File:
Mol file

Dextran Sulfate Sodium Salt Properties

storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to off-white
Water Solubility 
Soluble in water.
Merck 
2951
EPA Substance Registry System
Dextran, hydrogen sulfate, sodium salt(9011-18-1)

SAFETY

Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39-24/25
WGK Germany  2
RTECS  HH9290000
3-10
TSCA  Yes

Dextran Sulfate Sodium Salt price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade 9011-18-1 10gm-m $62.5 2017-11-08 Buy
Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade 9011-18-1 50gm-m $205 2017-11-08 Buy
Alfa Aesar J14489 Dextran sulfate sodium salt, Affymetrix/USB 9011-18-1 10g $152 2017-11-08 Buy
Alfa Aesar J14489 Dextran sulfate sodium salt, Affymetrix/USB 9011-18-1 50g $463 2017-11-08 Buy
Sigma-Aldrich 51227 Dextran sulfate sodium salt 25g $466.5 2017-11-08 Buy

Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.
  • Enzyme inhibition, activation and release
  • Adjuvant effect on immune response
  • Cellular interactions and response
  • Effect on virus infectivity

Uses

Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

Chemical Properties

White to off-white powder

Uses

Clinical reagent (HDL cholesterol determination).

Dextran Sulfate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products


Dextran Sulfate Sodium Salt Suppliers

Global( 133)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Herbon International Holdings Company Limited
(+86) 0762 3499809 ; (+86) 0762 3499803
chris.chan@herbon-international.com CHINA 3 55
Herbon International Polysaccharide Biotechnology (Heyuan) Co. Ltd. 0762 3499803;13377620238
- 2141594860@qq.com China 4 68
Beijing NuoqiYa Biotechnology Co., Ltd. 4000-819-385 010-62329685 13718666987
010-62340519 good@nuoqiya.com China 1978 55
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 18018719207
0755-85201366 sales@regentsciences.com China 298 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202,021-54302127,021-54308259,13764082696
+86-21-54291107 jerry.ma@hanhonggroup.com China 28711 64
BEST-REAGENT 028-85973071 028-85973075
028-85973075 service@best-reagent.com China 9966 57

9011-18-1(Dextran Sulfate Sodium Salt)Related Search:


  • asuro
  • dexnon
  • Dextran,hydrogensulfate,sodiumsalt
  • dextransodiumsulfate
  • dextransulfateso-saltfromleuconostocssp.
  • dextrarine
  • dexulate
  • ds-m-1
  • mds(polysaccharide)
  • Molecular Biology Reagents
  • Molecular Biology
  • Polysaccharide
  • SODIUM DEXTRAN SULFATE
  • SODIUM DEXTRAN SULFATE 5000
  • SODIUM DEXTRAN SULFATE 500,000
  • 9011-18-1
  • Biochemicals
  • Carbohydrates
  • BioChemical
  • Biochemicals and Reagents
  • DEXSATEMPO(TM)
  • DEXTRALIP(R) 50
  • DEXTRAN SULFATE
  • DEXTRAN SULFATE 500 NA-SALT
  • DEXTRAN SULFATE SODIUM
  • DEXTRAN SULFATE SODIUM SALT
  • DEXTRAN SULFATE SODIUM SALT 40
  • DEXTRAN SULFATE SODIUM SALT 500
  • DEXTRAN SULFATE SODIUM SALT LEUCONOSTOC SPP
  • DEXTRAN SULFATE, STERILE
  • DEXTRAN SULPHATE
  • DEXTRAN SULPHATE SODIUM
  • DEXTRAN SULPHATE SODIUM SALT
  • dextran sulfate (dextralip 50)
  • dextran sulfate av. mol. wt. 15,000
  • Dextran Sulfate, NA, MB Grade(1.03093)
  • Dextran sulffate sodium (from dextran of Mw. approx. 4,000)
  • DEXTRAN SULFATE AV. MOL. WT. 5,000*(LALL S)
  • DEXTRAN SULFATE SODIUM MOLECULAR*BIOLOGY REAGENT
  • DEXTRAN SULFATE SODIUM SALT, FROM LEUCONOSTOC SSP.
  • DEXTRAN SULFATE SODIUM AV. MOL. WT. OF*5 00,000
  • DEXTRAN SULFATE SO-SALT FROM LEUCONOSTOC SSP., MR ~500000
  • DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SSP., MW 100'000
  • DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SPP.
  • DEXTRAN SULFATE SODIUM AV. MOL. WT.*APPR OX. 8,000
  • DextranSulfate500,000Mw
  • DEXTRANSULFATE,50%SOLUTION,STERILE,BIOTECHGRADE
  • DEXTRANSULFATESODIUMSALT,POWDER
  • DEXTRANSULFATESODIUMSALT,POWDER,HEAVY
  • DEXTRANSULFATESODIUMSALT,POWDER,LIGHT
  • extran sulfate sodium
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 2.500)
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 4.000)
  • DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 25.000)
  • C6H7Na3O14S3n
  • Dextran sulphate sodium from leuconostoc 500,000
  • Dextran Sulfate 10,000
  • Dextrins、Sugar & Carbohydrates
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