3-(p-メトキシフェニル)-5,7-ジヒドロキシクロモン 化学特性,用途語,生産方法
外観
うすい黄色~黄色~黄赤色粉末~結晶
説明
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized
in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC
50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC
50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC
50 = 0.25 μM).
化学的特性
Off-White Solid
使用
An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene
一般的な説明
Biochanin A (BCA) is synthesized
in vitro from phloroglucinol. A series of steps involving Friedel?Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion.
3-(p-メトキシフェニル)-5,7-ジヒドロキシクロモン 上流と下流の製品情報
原材料
準備製品