10-ウンデセン酸 化学特性,用途語,生産方法
外観
白色/無色～うすい黄赤色～黄色粉末～塊～透明液体
定義
本品は、次の化学式で表される脂肪酸である。
溶解性
エタノールに溶ける。
解説
10-ウンデセン酸,脂肪および果実様の強い香気をもつ黄色の液体．融点24.5 ℃，沸点275 ℃，131 ℃(0.13 kPa)．d425"0.9072．nD25"1.447～1.450．水にほとんど不溶，エタノールに可溶．還元すればウンデカン酸に，酸化すればセバシン酸になる．皮膚疾患，白癬(せん)菌および糸状菌に対する治療薬として用いられる．
森北出版「化学辞典（第2版）
化粧品の成分用途
抗黴剤、乳化剤、殺菌剤、洗浄剤、香料
効能
抗真菌薬
製造
10-ウンデセン酸,ウンデシル酸ともいう．ひまし油の熱分解で得られる．
毒性
LD50 2500 mg/kg(ラット，経口)．
説明
Undecylenic acid (C11) or also called 10-undecenoic acid is an organic unsaturated fatty acid derived from castor oil by cracking. Undecylenic acid is an FDA approved active ingredient in medications for skin infections, and relieves itching, burning, and irritation. In technical applications it is used because if its antifungal properties.appearance (25°C) White or very pale yellow crystalline
mass or clear colourless pale
yellow liquid
acid value mg KOH/g 295 - 304
saponification mg KOH/g 295 - 304
iodine value) gI2/100g 132 - 136
congealing point °C 23 - 24
Purity by GC % min. 99%
化学的特性
Undecylenic acid is an organic unsaturated fatty acid derived from castor oil. It is the common name of 10-undecenoic acid, (CH
2CH(CH
2)
8COOH). It is used in the manufacture of pharmaceuticals, cosmetics and perfumery, including antidandruff shampoos , antimicrobial powders and as a musk in perfumes and aromas. Undecylenic acid is produced by cracking of castor oil under pressure.
天然物の起源
Reported found as a metabolite in Rhodotorula glutinis var. lusitanica; naturally occurring in the essential oils
of Juniperus chinensis, Thujopsis dolabrata and skim milk powder
使用
10-Undecenoic Acid, is used for the manufacture of pharmaceuticals, cosmetics and perfumery, including antidandruff shampoos, antimicrobial powders and as a musk in perfumes and aromas.
適応症
Undecylenic acid, like zinc undecylenate, is very effective as an external drug for treating
moderate dermatophyte infections and yeast dermatitis, but it is not effective for shingles and
for candida infections. Synonyms of this drug are benzevrine, micocid, undetin, and others.
製造方法
From malonic acid; by pyrolysis of ricinoleic acid or castor oil.
定義
ChEBI: An undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems.
一般的な説明
10-Undecenoic acid undergoes copolymerisation with ethylene using the metallocene catalyst system Cp
2ZrCl
2 / methylaluminoxane.
臨床応用
10-Undecenoic acid (Desenex, Cruex) obtained fromthe destructive distillation of castor oil. Undecylenic acidis a viscous yellow liquid. It is almost completely insolublein water but is soluble in alcohol and most organicsolvents.
Undecylenic acid is one of the better fatty acids for useas a fungicide, although cure rates are low. It can be used inconcentrations up to 10% in solutions, ointments, powders,and emulsions for topical administration. The preparationshould never be applied to mucous membranes because it isa severe irritant. Undecylenic acid has been one of theagents traditionally used for athlete’s foot (tinea pedis).Cure rates are low, however.
純化方法
Purify the acid by repeated fractional crystallisation from its melt or by distillation in a vacuum. [Beilstein 2 IV 1612.]
10-ウンデセン酸 上流と下流の製品情報
原材料
準備製品