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| | Levomepromazine hydrochloride Basic information |
| Product Name: | Levomepromazine hydrochloride | | Synonyms: | LevomepromazineHCl;10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (bR)- (9CI);10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (R)-;10-(3-Dimethylamino-2-methylpropyl)-2-methoxyphenothiazine hydrochloride;Levomepromazine hydrochloride;10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, monohydrochloride, (R)- (9ci);7044 Rp hydrochloride;Einecs 214-978-3 | | CAS: | 1236-99-3 | | MF: | C19H24N2OS.ClH | | MW: | 364.93 | | EINECS: | 214-978-3 | | Product Categories: | | | Mol File: | 1236-99-3.mol |  |
| | Levomepromazine hydrochloride Chemical Properties |
| Toxicity | LD50 oral in mouse: 380mg/kg |
| | Levomepromazine hydrochloride Usage And Synthesis |
| Originator | Levoprome ,Lederle,US,1966 | | Uses | Analgesic (central nervous system depressant). | | Definition | ChEBI: Levomepromazine hydrochloride is a member of phenothiazines. | | Manufacturing Process | 95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C. | | Brand name | Nozinan (Aventis). | | Therapeutic Function | Analgesic |
| | Levomepromazine hydrochloride Preparation Products And Raw materials |
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