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Sodium thioglycolate

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CAS:367-51-1
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  • Sodium thioglycollate
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  • 2024-04-25
  • CAS:367-51-1
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Sodium thioglycolate Basic information
Product Name:Sodium thioglycolate
Synonyms:SODIUM THIOGLYCOLLATE extrapure;Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt;Erhavit D;2-Mercaptoacetic acid sodium salt;Mercaptoacetic acid sodium;Sodium thioglycholate;Mercaptoacetic acid, sodium salt,98%;SODIUM THIOGLYCOLLATE (CULTURE MEDIA GRADE),
CAS:367-51-1
MF:C2H5NaO2S
MW:116.11
EINECS:206-696-4
Product Categories:Flotation;367-51-1
Mol File:367-51-1.mol
Sodium thioglycolate Structure
Sodium thioglycolate Chemical Properties
Melting point >300 °C (lit.)
vapor pressure <0.1 hPa (25 °C)
storage temp. -20°C
solubility 609.1g/l
pka3.82[at 20 ℃]
form solid
color White powder
OdorStench odour
PH Range6.5 - 8 at 114 g/l at 25 °C
PH6.7 (100g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Air Sensitive & Hygroscopic
Merck 14,8692
BRN 4569109
Exposure limitsACGIH: TWA 1 ppm (Skin)
LogP-2.99 at 20℃
CAS DataBase Reference367-51-1(CAS DataBase Reference)
EPA Substance Registry SystemSodium thioglycolate (367-51-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-38-36/37/38
Safety Statements 36-28-26
RIDADR 2811
WGK Germany 1
RTECS AI7700000
3-10-13-23
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29309070
ToxicityLD50 i.p. in rats: 148 mg/kg, Freeman, Rosenthal, Fed. Proc. 11, 347 (1952)
MSDS Information
ProviderLanguage
Mercaptoacetic acid sodium salt English
SigmaAldrich English
ACROS English
ALFA English
Sodium thioglycolate Usage And Synthesis
Chemical PropertiesWhite solid
UsesSodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Usesdipilatory, irritant, chelating agent
UsesIn cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid.
DefinitionThe sodium salt of thioglycolic acid.
General DescriptionWhite powder with a slight odor. Used in cold-waving of hair and as a dipilatory.
Air & Water ReactionsHygroscopic. Discolors on exposure to air. Water soluble.
Reactivity ProfileSodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.
HazardYields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.
Fire HazardFlash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.
Flammability and ExplosibilityNon flammable
Biochem/physiol ActionsSodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.
Safety ProfilePoison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.
Purification MethodsIt crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]
Sodium thioglycolate Preparation Products And Raw materials
Tag:Sodium thioglycolate(367-51-1) Related Product Information
Sodium glycolate 2-Mercaptobenzothiazole Sodium acetate Diphenolic acid Sodium chloride Sodium benzoate 4-(Diethylamino)salicylaldehyde 6-Mercaptopurine 3-Mercaptopropionic acid Ammonium thioglycolate DL-α-Tocopherol Sodium gluconate Sodium carbonate Sodium hydroxide Calcium thioglycolate Sodium thiophosphate 5-Chlorovaleric acid Ethanethiol