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| | Roquinimex Basic information |
| Product Name: | Roquinimex | | Synonyms: | N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide | | CAS: | 84088-42-6 | | MF: | C18H16N2O3 | | MW: | 308.33 | | EINECS: | | | Product Categories: | Antitumour | | Mol File: | 84088-42-6.mol |  |
| | Roquinimex Chemical Properties |
| Melting point | 200-204° | | Boiling point | 436.2±45.0 °C(Predicted) | | density | 1.357±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: 11 mg/mL | | pka | 4.50±1.00(Predicted) | | form | solid | | Merck | 14,8259 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36/37 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | HS Code | 2933.49.2600 |
| | Roquinimex Usage And Synthesis |
| Description | Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model. | | Uses | An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats | | Uses | Biological response modifier; immunomodulator. | | Definition | ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide. | | Biological Activity | Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo . |
| | Roquinimex Preparation Products And Raw materials |
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