|Company Name:||J & K SCIENTIFIC LTD. |
|Company Name:||INTATRADE GmbH |
|Product Name:||Vitamin D2|
|Synonyms:||VITAMIN D;VITAMIN D2;VITAMIN D2 WATER;VIOSTEROL;(3beta,5Z,7E,22E)-9,10-Secoerga-5,7,10(19),22-tetraen-3-ol;(3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19)-,22-tetraen-3-ol;(3-beta,5z,7e,22e)-9,10-secoergosta-5,7,10,(19),22-tetraen-3-ol;(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol|
|Product Categories:||Vitamins - Deuterated;Biochemistry;Vitamins;Nutritional Supplements;Vitamins and derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Mainly used for the prevention and treatment of rickets osteomalacia baby brothers tetany, etc;Vitamin series;DRISDOL;Isolabel;Inhibitors|
|Vitamin D2 Chemical Properties|
|mp ||114-118 °C(lit.)|
|alpha ||82 º (c=3, in acetone 25 ºC)|
|Fp ||14 °C|
|storage temp. ||2-8°C|
|solubility ||H2O: 200 mg/mL, clear to hazy|
|CAS DataBase Reference||50-14-6(CAS DataBase Reference)|
|NIST Chemistry Reference||Ergocalciferol(50-14-6)|
|EPA Substance Registry System||9,10-Secoergosta- 5,7,10(19),22-tetraen-3-ol, (3.beta.,5Z,7E,22E)-(50-14-6)|
|Vitamin D2 Usage And Synthesis|
|Vitamin D||Vitamin D refers to a group of fat-soluble steroid compounds with anti-rickets effect and is called anti-rickets vitamin. It is known currently about at least ten or more sterols substance with vitamin D activity. They are mainly presented in the vegetable oil or yeast ergosterol solid which subject to sunlight or ultraviolet irradiation to generate vitamin D2 which is also called as calciferol or ergocalciferol. Therefore, ergosterol is also called as original vitamin D2; the other is from that the human body can convert the cholesterol to the 7- dihydro-cholesterol to be stored in the skin with the later being able to be converted to vitamin D3 upon sunlight and ultraviolet radiation. Vitamin D3 is also known as cholecalciferol and therefore the 7-dehydrocholesterol is also known as original vitamin D3. Vitamin D2 has a very similar structure with vitamin D3 and both of them are the B ring open-ring derivatives of precursor sterols with the difference of them being laid in a extra double bond and a methyl group in the side chain of vitamin D2.|
Both vitamin D2 and vitamin D3 are colorless or white crystals and are not foul with the melting point being 115 ~ 118 ℃ and 84 ~ 85 ℃, respectively. They are insoluble in water and easily soluble in alcohol, ether, acetone, and slightly soluble in vegetable oil. They are unstable in air and sunlight and are easily inactivated in moist air. However, vitamin D3 is relatively more stable than vitamin D2. These two have similar physiological roles in the human body with the major role being maintain the normal metabolism of calcium and phosphorus, promoting the deposition of calcium and phosphorus into the bone and tissue and thus it can be used in prevention and treatment of metabolic bone disease such as rickets and osteomalacia.
Vitamin D2 and D3 have the same effects on mammals and cows and pigs. However, vitamin D3 has a ten times stronger activity on poultry (birds) than vitamin D2.
Vitamin D deficiency can reduce the intestinal absorption of calcium and cause the decomposition of bone calcium and phosphorus. Young livestock will get osteomalacia and adult animals are prone to osteoporosis. Vitamin D deficiency can also lead to animal sternum and spine deformation and that layers give birth to soft-shell eggs. Because vitamin D control the absorption of calcium, phosphorus, too much absorption of vitamin D in the diet can cause high blood calcium, so that excess calcium can be deposited in the heart, blood vessels, joints, pericardium or intestinal wall, leading to heart failure, joint stiffness or intestines disorders.
Sunbathing is the most economical source of getting vitamin D. The ergosterol or 7-dehydrocholesterol can be converted into vitamin D inside animal body upon ultraviolet radiation. The hay, yeast, corn leaves, barley, oats, wheat under sunshine and yeast which has been subject to ultraviolet treatment is a good source of vitamin D. Animal products can directly provide vitamin D for the livestock, such as eggs, milk. Cod liver oil is rich in vitamin D levels. Reared animals and animal with insufficient sunlight need to have their daily feed supplied with additional vitamin D.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
|Toxicity||Acute toxicity dose: 100 mg/d (adult, orally). Mouse lethal dose of 20mg / kg (6 Day). Excess can easily cause poisoning. |
GRAS (FDA, §182.5950, 2000).
LD50: 42mg/kg (rat, oral).
|Limited use||GB 14880-94 (μg / kg): liquid milk from 10 to 20; margarine: 125 to 156; dairy products: 63 to 125; milk and milk drinks: 10 to 40; infant and children food: 50 to 115. |
GB 2760-2002 (pg / kg): solid drink, ice cream, 10 to 20; arrowroot flour: 50 to 100; Soy milk, soy flour, 15 to 60; soy milk, soy milk, 3 to 15; jelly: 10 to 40; instant breakfast cereals, 12.5 to 37.5; puffed food sandwich from 10 to 60.
FDA, §184.1950 (IU / 100g; 2001): breakfast cereals 350; 90 granular and pasty products; milk 42; 89 dairy products.
|The maximum allowable amount as food additives and maximal allowable residue limits|
|Chemical Properties||It is white needle crystal or crystalline powder and is odorless and tasteless. Its melting point is 115-118 ℃ (decomposition), Its specific rotation is [α]20D+102.5°(ethanol). The ethanol solution of this product has maximum absorption at 265nm wavelength. It is soluble in ethanol (1: 2), diethyl ether (1: 2), acetone (1:10) and chloroform (1: 0.7) but insoluble in water. Moreover, it has a lower activity in case of light or oxygen.
|Application||It can be applied to biochemical studies; its clinical drug belongs to a lipid-soluble vitamin which can promote the intestinal absorption of calcium and phosphorus which plays a role of facilitating the calcification of bone. It is clinically used for prevention and treatment of rickets in children and adult osteomalacia. |
Vitamin D2 can maintain the normal metabolism of calcium and phosphorus and can also promote the body's absorption of calcium and phosphorus. Upon its deficiency, the children are easy to get rickets. China ruled that it can be applied for strengthening margarine with the usage amount being 125 ~ 156 μg / kg; its usage amount in fortified dairy is 63 ~ 125μg / kg; the usage amount in strengthening infant and children food used is 50 ~ 100μg / kg; the usage amount in strengthening milk or milk beverage is 10 ~ 40μg / kg; the maximal allowable usage amount in the strengthening solid drinks and ice cream is 10 ~ 20μg / kg.
It is mainly applied to the prevention and treatment of rickets, osteomalacia, and infant tetany psychosis.
|Production method||Dissolve the ergosterol dissolved in ethanol and go through ring-opening under UV illumination; the reaction was further concentrated under reduced pressure, frozen, filtered, and filtered of liquid nitrogen, and concentrated under reduced pressure to dryness to obtain the crude oil of vitamin D2 with distillation to obtain the refined products. |
Vitamin D2 is naturally presented in the liver, egg yolk and milk; the production method of the industry starts with extracting the ergocalciferol from vegetable oil or yeast extract in the body. Further dissolve it in chloroform or cyclohexane, and then convert it to the vitamin D2 through ultraviolet radiation on the quartz glass flask.
Ergosterol ethanol solution is subject to ultraviolet radiation with the 9’, 10’ bond breakage to obtain the vitamin D2 crude product; the later one further has esterification with 3, 5-nitrobenzoyl chloride and undergoes alkaline hydrolysis to get the purified product.
|Usage||The synthetic form of vitamin D. Prepared from ergosterol by UV irradiation in a suitable solvent. Commercial solutions are usually made with propylene glycol or sesame oil. Antirachitic|
|Usage||antirachitic vitamin; LD50 (rat) 56 mg/kg po|
|General Description||Odorless white crystals. Used as a dietary supplement and food additive.|
|Reactivity Profile||Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.|
|Health Hazard||Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.|
|Fire Hazard||Shows signs of decomposition when stored for a few days at room temperature.|
|Vitamin D2 Preparation Products And Raw materials|