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| | Amsacrine hydrochloride Basic information |
| Product Name: | Amsacrine hydrochloride | | Synonyms: | m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride;Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride;Methanesulfon-m-anisidide 4'-(9-acridinylamino)-;Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride;4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE;M-AMSA HYDROCHLORIDE;M-AMSA, HCL;Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride | | CAS: | 54301-15-4 | | MF: | C21H20ClN3O3S | | MW: | 429.92 | | EINECS: | 637-255-8 | | Product Categories: | | | Mol File: | 54301-15-4.mol |  |
| | Amsacrine hydrochloride Chemical Properties |
| Melting point | 197-199 °C(lit.) | | storage temp. | Refrigerator | | solubility | DMSO: 10 mg/mL with heat and sonication | | form | powder | | color | red to brown |
| Hazard Codes | T | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | PB1081000 | | HS Code | 2933.99.8290 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | Amsacrine hydrochloride Usage And Synthesis |
| Uses | Amsacrine hydrochloride has been used:
- as a topoisomerase poison in bacteriophage T4 topoisomerase assay
- as a topoisomerase inhibitor in Drosophila cell line, Kc167
- as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
- as a topoisomerase II poison in dose-response assays in C elegans
| | Biological Activity | amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1]. | | Biochem/physiol Actions | Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery. | | references | [1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5. |
| | Amsacrine hydrochloride Preparation Products And Raw materials |
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