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Dexamethasone

Dexamethasone Suppliers list
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Dexomethasone
CAS:50-02-2
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
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Products Intro: Product Name:Dexamethasone
CAS:50-02-2
Purity:98% Package:6600/KG
Company Name: Wuhan Hezhong Bio-chemical Manufacture co ltd  Gold
Tel:021-68580715 / 18930710487
Email:nikki@pharm-china.com
Products Intro:Product Name:Dexamethasone
CAS:50-02-2
Purity:99% HPLC Package:100G;500G;1KG;5KG
Company Name: Taizhou DongBang Fine Chemical Co. Ltd.  Gold
Tel:+86-0523-86235448 15996000437
Email:2535251509@qq.com
Products Intro:Product Name:Dexamethasone-17-acetate
CAS:50-02-2
Purity:99%
Company Name: Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.  Gold
Tel:027-65388397 18164111589
Email:3321478047@qq.com
Products Intro:Product Name:Dexamethasone
CAS:50-02-2
Purity:99% Package:1g.10g.100g.500g,1kg.25kg
Dexamethasone Basic information
Description Side Effects Drug Reactions
Product Name:Dexamethasone
Synonyms:16alpha)-;16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet;16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione;16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2;16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione;16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien;16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione;16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol
CAS:50-02-2
MF:C22H29FO5
MW:392.46
EINECS:200-003-9
Product Categories:Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Steroid and Hormone;Pharmaceutical intermediate;API;MAXIDEX;Hormone Drugs;Mainly used for anti-inflammatory and allergy;Pharmaceutical intermediates;pharmaceutical intermediate and medicine grade
Mol File:50-02-2.mol
Dexamethasone Structure
Dexamethasone Chemical Properties
Melting point 262-264 °C(lit.)
alpha 75 º (c=1, dioxane)
refractive index 76 ° (C=1, Dioxane)
Fp 9℃
storage temp. 2-8°C
solubility ethanol: 1 mg/mL
form powder
color off-white
Water Solubility 10 mg/100 mL (25 ºC)
Sensitive Light Sensitive
Merck 14,2943
BRN 2066651
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
CAS DataBase Reference50-02-2(CAS DataBase Reference)
NIST Chemistry ReferencePrednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
EPA Substance Registry SystemPregna-1,4-diene- 3,20-dione, 9-fluoro-11,17,21-trihydroxy- 16-methyl-, (11.beta.,16.alpha.)-(50-02-2)
Safety Information
Hazard Codes Xi,Xn,T,F
Risk Statements 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11
Safety Statements 36/37-45-36-26-22-16
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 2
RTECS TU3980000
TSCA Yes
Hazardous Substances Data50-02-2(Hazardous Substances Data)
MSDS Information
Dexamethasone Usage And Synthesis
DescriptionDexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cd k2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Dexamethasone regulates T cell survival, growth, and differentiation.Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
Side EffectsDexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include:
It can cause stomach discomfort and increased sensitivity to stomach ulcers.
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Drug ReactionsDexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Amphotericin
Aspirin
Cyclophosphamide
Cyclosporine
Digoxin
Daunorubicin HCl
Doxorubicin HCl
Insulin
Mitotane
Phenobarbital
Phenytoin sodium
Rifampin
Rimadyl
General DescriptionOdorless white to off-white crystalline powder with a slightly bitter taste.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileDexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
Fire HazardFlash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.
Biological ActivityGlucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.
Dexamethasone Preparation Products And Raw materials
Preparation ProductsBECLOMETHASONE
Tag:Dexamethasone(50-02-2) Related Product Information
DEXAMETHASONE HEMISUCCINATE Fluocoutolone Hexanoate PARAMETHASONE ACETATE (200 MG) Paramethasone dexamethasone 21-methanesulfonate dexamethasone trimethyl acetate 6-BETA-HYDROXYDEXAMETHASONE Halometasone Flumethasone-17-acetate DEXAMETHASONE SODIUM PHOSPHATE DEXAMETHASONE, [6,7-3H]- DEXAMETHASONE 21-O-BETA-D-GALACTOPYRANOSIDE 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) Vaderm 1,4-PREGNADIEN-11-BETA, 21-DIOL-3,20-DIONE 21-HEMISUCCINATE Dexamethasone Dexamethasone sodium phosphate Fluorine