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Apixaban

Apixaban Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Apixaban
CAS:503612-47-3
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Apixaban
CAS:503612-47-3
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Suzhou Carbonwell Pharma-Tech Co., Ltd  Gold
Tel:86-512-88981216 18606258602
Email:info@carbonwell.com
Products Intro:Product Name:Apixaban
CAS:503612-47-3
Purity:>99.5%, any impurity<0.05% Package:1.0kg; 5.0kg; 10.0kg; 20.0kg
Company Name: ChemFuture PharmaTech (Jiangsu) Ltd  Gold
Tel:86 510 85386188 ;86 510 85386988-8021
Email:Sales@chemfuture.com
Products Intro:Product Name:1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
CAS:503612-47-3
Remarks:CFP8050
Company Name: Chongqing Dinpan Pharmaceutical Co., Ltd.  Gold
Tel:023-63118685 13637821125
Email:lap2528@163.com
Products Intro:CAS:503612-47-3
Purity:99% Package:1kg,5kg
Apixaban Basic information
Indications and Usage Mechanisms of Action Clinical Research Drug Interactions Warnings and Precautions
Product Name:Apixaban
Synonyms:Apixaban;Apixaban, BMS 562247-01;1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide;BMS 562247-01;1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid aMide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4, 5-dihydropyrazolo[3,4-c]pyridine-3-carboxaMide;Nilotinib and its interMediate
CAS:503612-47-3
MF:C25H25N5O4
MW:459.504
EINECS:
Product Categories:Inhibitor;Inhibitors
Mol File:503612-47-3.mol
Apixaban Structure
Apixaban Chemical Properties
density 1.42
Safety Information
MSDS Information
Apixaban Usage And Synthesis
Indications and UsageApixaban is a new form of oral anticoagulant drug developed by Bristol Myers Squibb and Pfizer. It is a new form of oral Xa factor inhibitor, and its commercial name is Eliquis. Apixaban is used to treat adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE)
Mechanisms of ActionApixaban is an oral selective activated Xa factor inhibitor and can prevent thrombin generation and thrombosis.
Clinical ResearchApixaban is the third new oral anticoagulant to go on sale, following dabigatran and rivaroxaban, and it has already been approved in Europe for preventing venous thromboembolism in patients undergoing elective hip or knee replacement surgery. Out of these three oral anticoagulants approved in Europe, compared to the current standard preventative treatment against venous thromboembolism, enoxaparin, rivaroxaban excelled in the record experiment, and apixaban excelled in the advance experiment. Rivaroxaban’s curative effects were slightly superior, but it caused more severe bleeding than apixaban. Researchers attributed these differences to medication time, as rivaroxaban was taken 6-8 hours after surgery in the record experiment, while apixaban was used 18 hours after surgery in the advance experiment. These drugs have better curative effect when used closer to time of surgery, but also have an increased bleeding risk. Clinical research showed that compared to a daily subdermal injection of 40mg enoxaparin, 2 oral 2.5mg dosages of apixaban had better preventative effects against venous thromboembolism following hip or knee replacement surgery and did not increase bleeding risk.
Drug Interactions1.A double inhibitor of strong CYP3A4 and P-gp increases apixaban’s blood levels: decrease Eliquis dosage to 2.5mg or avoid simultaneous usage.
2.A inductor of strong CYP3A4 and P-gp can decrease apixaban’s blood levels: avoid simultaneous usage.
Warnings and Precautions
  • Breastfeeding mothers should stop usage or stop breastfeeding.
  • Use during pregnancy is not advised.
  • Use while experiencing severe liver damage is not advised.
UsesApixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
DefinitionChEBI: A pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases.
Apixaban Preparation Products And Raw materials
Tag:Apixaban(503612-47-3) Related Product Information
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