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Modafinil

Modafinil Basic information
Description References
Product Name:Modafinil
Synonyms:MODAFINIL;2-(BENZHYDRYLSULFINYL)ACETAMIDE;2-[(DIPHENYLMETHYL)SULFINYL]ACETAMIDE;AKOS BC-1794;MODAFINIL-DEA SCHEDULE IV;CRL-40476;Provigi;MODAFINIL INTERMEDIATE:DIPHENYL METHANESULFONYLACETAMIDE
CAS:68693-11-8
MF:C15H15NO2S
MW:273.35
EINECS:200-835-2
Product Categories:Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;LOTENSIN
Mol File:68693-11-8.mol
Modafinil Structure
Modafinil Chemical Properties
Melting point 164-166°C
Fp 2℃
storage temp. Store at +4°C
solubility DMSO: 18 mg/mL, soluble
color white
CAS DataBase Reference68693-11-8(CAS DataBase Reference)
Safety Information
Hazard Codes T+,Xn,F
Risk Statements 26/27/28-36-20/21/22-11
Safety Statements 24/25-45-36/37/39-22-36/37-16
RIDADR UN 1648 3 / PGII
WGK Germany 3
Hazardous Substances Data68693-11-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
2-[(Diphenylmethyl)sulfinyl]-acetamide English
SigmaAldrich English
Modafinil Usage And Synthesis
DescriptionMarketed as a wakefulness promoting agent, modafinil belongs to the group of medicines known as central nervous system (CNS) stimulants, which is commonly used to promote wakefulness and reduce excessive daytime sleepiness in patients with narcolepsy, obstructive sleep apnea, hypopnea syndrome, shift-work sleep disorder or circadian rhythm sleep disorder. Besides, recently studies have showed that modafinil may be effective to help cocaine addicts fight against their addiction.
The sleepiness-preventing effects of modafinil functions by stimulating certain parts of the brain, in which the neurons are activated by modafinil. It binds to the dopamine reuptake pump so as to inhibit the reuptake of dopamine from the cell, while the extracellular dopamine increases, thus preventing drowsiness and keeping people from falling asleep.
Referenceshttps://en.wikipedia.org/wiki/Modafinil
http://bodyandhealth.canada.com/drug/getdrug/apo-modafinil
https://www.drugbank.ca/drugs/DB00745
Chemical PropertiesCrystalline Solid
UsesA central nervous system vigilance promoting agent. Possesses neuroprotective properties. This is a controlled substance (stimulant)
UsesACE inhibitor, antihypertensive
UsesModafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
Biological ActivityPsychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Modafinil Preparation Products And Raw materials
Tag:Modafinil(68693-11-8) Related Product Information
(R)-(-)-Modafinil Acid,(R)-Modafinil Carboxylate (S)-(+)-Modafinil,(S)-Modafinil MODAFINIL CARBOXYLATE Modafinil-D5,(R)-(-)-Modafinil-d5,(R)-Modafinil-d5,(S)-(+)-Modafinil-d5,(S)-Modafinil-d5 Modafinil Acid (R)-Modafinil Carboxylate (S)-a-Methylbenzenemethanamine Salt MODAFINIL FOR SYSTEM SUITABILITY Modafinil-d5 (Mixture of diastereomers) (R)-Modafinil Carboxylate Methyl Ester Modafinil Carboxylate Sulfone MODAFINIL SULFONE Modafinil Carboxylate-d5,Modafinil-d5 Acid N-Acetylsulfanilyl chloride N,N-Dimethylacetamide 2-Phenylacetamide Modafinil Acetamide N-Methylacetamide