L-甲状腺素
中文名称 | L-甲状腺素 |
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中文同义词 | L-Β-(3,5-二磺-4-羟基苯氧基)-3,5-二磺苯丙氨酸;左旋甲状腺素;O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸;L-甲状腺素(标准品);左甲状;3,5,3',5'-四碘甲状腺胺酸;L-甲状腺激素;3,3\',5,5\'-四碘-L-甲腺原氨酸 |
英文名称 | L-Thyroxine |
英文同义词 | 3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine;3,5,3',5'-TETRAIODO-L-THYRONINE;3,3',5,5'-TETRAIODO-L-THYRONIN;3,3',5,5'-TETRAIODO-L-THYRONINE |
CAS号 | 51-48-9 |
分子式 | C15H11I4NO4 |
分子量 | 776.87 |
EINECS号 | 200-101-1 |
相关类别 | 医药原料;饲料添加剂;小分子抑制剂;原料;小分子抑制剂,天然产物;杂环化合物;医药中间体;激素;生化试剂;生物化学品;原料药;医药级;Pyridines ,氟化学;氨基酸类;内分泌与激素;Amino Acids;Organics;Heterocyclic Compounds;Isotope Labeled Compounds;氨基酸;细胞生物学;兽药级;化合物;化学试剂;对照品;其他生化试剂;前列素系列;有机中间体;其他;中药对照品;化工原料;主营产品;化学试剂;通用生化试剂-氨基酸;医用原料;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Isotope Labelled Compounds;SYNTHROID;Isolabel;Other APIs;Inhibitors |
Mol文件 | 51-48-9.mol |
结构式 |
L-甲状腺素 性质
熔点 | 235 °C |
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比旋光度 | -5 º (1N NaOH:EtOH 1:2) |
密度 | 2.4440 (estimate) |
闪点 | 9℃ |
储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | 以50mg/ml溶于4M氢氧化铵的甲醇溶液 |
酸度系数(pKa) | 2.2(at 25℃) |
形态 | 粉末 |
沸点 | 576.3±50.0 °C(Predicted) |
颜色 | 白色至浅棕色 |
旋光性 (optical activity) | -4.5 to -5.7 [1 mol dm-3 NaOH-ethanol (1:2)] +15 [1 mol dm-3 HCl-95% ethanol (1:2)] |
水溶解性 | insoluble |
敏感性 | Light Sensitive |
Merck | 9491 |
BRN | 2228515 |
InChIKey | XUIIKFGFIJCVMT-LBPRGKRZSA-N |
CAS 数据库 | 51-48-9(CAS DataBase Reference) |
EPA化学物质信息 | L-Thyroxine (51-48-9) |
Human Endogenous Metabolite
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Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).
安全信息
危险品标志 | Xn,T,F |
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危险类别码 | 40-39/23/24/25-23/24/25-11 |
安全说明 | 22-24/25-36-45-36/37-16 |
危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS号 | YP2833500 |
F | 8-10 |
TSCA | Yes |
危险等级 | IRRITANT |
海关编码 | 29379000 |
毒害物质数据 | 51-48-9(Hazardous Substances Data) |
毒性 | TDLo oral in child: 328ug/kg |
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