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Fasudil hydrochloride

Fasudil hydrochloride Suppliers list
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Fasudil hydrochloride
CAS:105628-07-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
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Products Intro: Product Name:Fasudil hydrochloride
CAS:105628-07-7
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
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Products Intro: Product Name:Fasudil hydrochloride
CAS:105628-07-7
Company Name: Tianjin Chase Sun Pharmaceutical Co., Ltd  Gold
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Products Intro:Product Name:Fasudil hydrochloride
CAS:105628-07-7
Purity:98.5% Package:1kg, 10kg, 25kg
Company Name: Changzhou Wanyao Biotechnology Co., Ltd.  Gold
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Products Intro:Product Name:Fasudil hydrochloride
CAS:105628-07-7
Fasudil hydrochloride Basic information
Indications and Usage Mechanisms of Action Adverse reactions Warnings and Precautions
Product Name:Fasudil hydrochloride
Synonyms:1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE;HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE;HA-1077;HA-1077 DIHYDROCHLORIDE;FASUDEL;FASUDIL DIHYDROCHLORIDE
CAS:105628-07-7
MF:C14H18ClN3O2S
MW:327.83
EINECS:
Product Categories:APIs;API;Inhibitor;Cardiovascular & Blood System Agents;Inhibitors
Mol File:105628-07-7.mol
Fasudil hydrochloride Structure
Fasudil hydrochloride Chemical Properties
solubility H2O: >200 mg/mL
form solid
color white
Water Solubility Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
CAS DataBase Reference105628-07-7(CAS DataBase Reference)
Safety Information
Risk Statements 22
Safety Statements 36-60
WGK Germany 3
RTECS HM4031166
MSDS Information
ProviderLanguage
SigmaAldrich English
Fasudil hydrochloride Usage And Synthesis
Indications and UsageFasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Mechanisms of ActionFasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
Adverse reactionsAdverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
Warnings and PrecautionsPatients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
Usesvasodilator, potent Rho-kinase inhibitor
Fasudil hydrochloride Preparation Products And Raw materials
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