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Tilmicosin

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Tilmicosin Basic information
Brief introduction Chemical Properties Uses
Product Name:Tilmicosin
Synonyms:20-DEOXO-20-(3,5-DIMETHYL-1-PIPERIDINYL)DESMYCOSIN;TILMICOSIN;Tilmicosin, Vetranal;Tilmicosine;Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-;pulmotil;4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin;Antibiotic EL 870
CAS:108050-54-0
MF:C46H80N2O13
MW:869.13
EINECS:
Product Categories:Active Pharmaceutical Ingredients;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;API
Mol File:108050-54-0.mol
Tilmicosin Structure
Safety Information
Hazardous Substances Data108050-54-0(Hazardous Substances Data)
MSDS Information
Tilmicosin Usage And Synthesis
Brief introductionTilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl -3-C- -L- ribose -pyran-hexyl) -20-deoxy-20- (3,5-dimethyl-1-piperidinyl) - [20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15.
Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti- Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil © Micotil ©, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin.
Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical PropertiesIt is white or white powder with humidity: ≤5.0%.
UsesIt can be used as anti-bacterial.
It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.
Chemical PropertiesWhite Solid
UsageTilmicosin is a semi-synthetic antibiotic derived from desmycosin (tylosin B), a minor co-metabolite of tylosin. Tilmicosin is produced by reductive amination of desmycosin. Desmycosin itself is prepared by the partial hydrolysis of tylosin with the loss of the mycarosyl sugar. The piperidinyl group at C20 of tilmicosin provides a wider spectrum of antibiotic action, in particular good protection against Pasteurella in livestock.
UsageMacrolide antibiotic structurally related to tylosin. Antibacterial
Tilmicosin Preparation Products And Raw materials
Tag:Tilmicosin(108050-54-0) Related Product Information
Dacthal Dimethyl ether (R)-3-METHYL-4-TETRAHYDROPYRANYLOXYBUTYLAMINE TMC 016 ISO-PROPYL-UNDECYLENATE 8,10-DODECADIEN-1-OL TILMICOSIN PHOSPHATE 4-(3,5-DIMETHYLPIPERIDIN-1-YL)BUTAN-1-OL METHYL-BETA-D-RIBOPYRANOSE Tilmicosin Dimethyl fumarate Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate Tilmicosin phosphate Dimethyl carbonate ETHANE N,N-Dimethylformamide