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Cyproheptadine hydrochloride

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Products Intro: Product Name:Cyproheptadine hydrochloride
CAS:41354-29-4
Purity:99% Package:1550/KG
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Products Intro:Product Name:yproheptadine hydrochloride sesquihydrate
CAS:41354-29-4
Purity:99% Package:1kg,5kg,25kg
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Products Intro:Product Name:Cyproheptadine hydrochloride
CAS:41354-29-4
Purity:99.0% Package:1kg;5kg;10kg
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Products Intro:CAS:41354-29-4
Company Name: Jinan Jason Pharmaceutical Co., Ltd.  Gold
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Products Intro:Product Name:Cyproheptadine hydrochloride
CAS:41354-29-4
Purity:99%min
Cyproheptadine hydrochloride Basic information
Antihistamines Uses
Product Name:Cyproheptadine hydrochloride
Synonyms:CYPROHEPTADINE HCL;CYPROHEPTADINE HYDROCHLORIDE;CYPROHEPTADINE HYDROCHLORIDE HYDRATE;CYPROHEPTADINE HYDROCHLORIDE SESQUIHYDRATE;4-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDINE)-METHYLPIPERIDINE HYDROCHLORIDE;CYPROHEPTADINE HCL USP(CRM STANDARD);CYPROHEPTADINE HYDROCHLORIDE EPC(CRM STANDARD);CyproheptadineHclUspGrade
CAS:41354-29-4
MF:C21H22ClN
MW:323.86
EINECS:213-535-1
Product Categories:Building Blocks;Heterocyclic Building Blocks;Piperidines;API;PERIACTIN
Mol File:41354-29-4.mol
Cyproheptadine hydrochloride Structure
Cyproheptadine hydrochloride Chemical Properties
Melting point 165 °C (dec.)(lit.)
solubility ethanol: soluble
color white to slightly yellow
λmax285nm(0.05mol/L H2SO4)(lit.)
Merck 14,2773
CAS DataBase Reference41354-29-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS TM7050000
HazardClass 6.1
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
Cyproheptadine hydrochloride Usage And Synthesis
AntihistaminesCyproheptadine hydrochloride is a kind of pipecolic antihistamines,it can compete with histamine released from the organization for H1 receptor on effector cells , thereby it can prevent the onset of an allergic reaction, and release histamine-induced spasm and congestion effects, this product has a strong H1 receptor antagonism, its anti-histamine effect is stronger than chlorpheniramine, promethazine . There are mild to moderate anti-serotonin effects and anticholinergic effects. In addition, there is a stimulate appetite effect, and weight gains after a certain time.
Clinically cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially it has a good effect on cold urticaria ), papular urticaria, angioedema, atopic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, allergic to insect stings and migraine. It has some therapeutic effect on bronchial asthma . It is acceptable for the adjuvant treatment of Cushing's syndrome, acromegaly. In addition,as an appetite enhancer,it is used for neuropathic fear of food. There are reports about acanthosis nigricans treatment, prevention of necrotizing pyoderma.
【Dosage 】oral often release dosage : (1) allergic diseases: adult, once 2~4mg, one day 2 or 3 times. (2) Cushing's syndrome, applicable to the treatment of cases of bilateral adrenal hyperplasia,it can inhibit the hypothalamic release of corticotropin releasing hormone (CRH) and inhibit the secretion of pituitary adrenocorticotropic hormone (ACTH), thereby lowering plasma ACTH and cortisol levels; adults start one day 8mg,which can be gradually increased to one day24mg; the usual dose is one day 12~24mg, divided doses,it needs long-term use; in the case of cortical function inadequate after total resection or subtotal bilateral adrenal, on one hand ,supple corticosteroids, on the other hand,take cyproheptadine,which can reduce the chance of occurrence of pituitary tumors.
The above information is edited by the chemicalbook of Tian Ye.
UsesAnticoagulant, anti-allergic drugs. It can be used for urticaria, eczema, and allergic contact dermatitis, skin itching and other allergic reactions. It can also be used for Cushing's diseases and acromegaly.
UsesH1-antihistamine, antipruritic
UsesCyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H 1 histamine receptor antagonist; antipruritic.
DefinitionChEBI: The sesquihydrate of cyproheptadine hydrochloride. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate. A sedating antihistamine with antimuscarinic and calcium-channel blocking actions, it i used for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Cyproheptadine hydrochloride Preparation Products And Raw materials
Raw materialsPhenylacetic acid
Tag:Cyproheptadine hydrochloride(41354-29-4) Related Product Information
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